Lipids Fredrickson Classification

Question 1

High CM
Creamy layer over clear plasma
Refrigerator test positive

Answer 1

Type I Hyperlipidemia

Question 2

Increased LDL
Clear plasma

Answer 2

Type IIa

Question 3

Increased LDL and VLDL
Slightly turbid plasma

Answer 3

Type IIb

Question 4

Increased Beta-VLDL
Turbid

Answer 4

Type III

Question 5

Increased VLDL
Turbid to Milky

Answer 5

Type IV

Question 6

Increased VLDL and CM
Creamy layer over turbid suspension
Refrigerator test positive

Answer 6

Type V

Question 7

Enumerate the particle component of each classical hyperlipidemia

Answer 7

Type 1, 4 - Increased TGs
Type 2A - Increased CHOLE
Type 2B, 3, 5 - Increased TGs and CHOLE

Question 8

What does creamy top supernatant indicate?

Answer 8

Indicative of chylomicrons, which is the least dense lipoprotein, hence there is a tendency to float.

Question 9

What does clear supernatant indicate?

Answer 9

Indicative of high cholesterol content

Question 10

What does turbid/milky/cloudy supernatant indicate?

Answer 10

Indicative of high TG but specifically refers to VLDL due to density factors and molecular factors