Lipid lowering drugs Flashcards
Which drugs can increase HDL?
HMG CoA reductase inhibitors
Niacin
Ezetimibe
If a patient has type 1 diabetes or a chronic kidney disease or a 10 year cardiovascular risk, how should u treat them?
Atorvastatin 20mg
When should statins be administered?
At night
What are the uses of statins?
all types of hyperlipidemias except Familial
Which drugs treat familial hyperlipodemias?
Cholestyramine
Niacin
which drug may cause myopathies or liver impairment? and who is it contraindicated in?
Statins
- alcoholics
- acute liver disease
- pregnancy & lactation
What are the DDIs of statins?
- Macrolides (clarithromycin): increase myopathy risk
- Alcohol: hepatotoxicity
- Warfarin: increase anticoagulation
Which drug activate the PPAR alpha receptor and decreases LDL & TAG?
Fibrates (Gemfibrozil & fenofibrate)
USED FOR HIGH TAG LEVELS
Which drug could cause thromboembolism? what are its contraindications
FIBRATES
contraindicated in: gallbladder disease, gallstones, and severe hepatic or renal dysfunction
What are the DDIs of Fibrates?
increases effects of Warfarin (check INR)
which drug increase excretion of bile acids in intestines? and where is it contraindicated?
Cholestyramine
hypertriglyceridemia >400
Which drug is used in pruritus due to biliary stasis?
Cholestyramine
What are the DDIs of Cholestyramine?
- impairs absorption of vitamins A D E K
- interfere with absorption of digoxin, thyroid hormone, and warfarin
What inhibits lipolysis in adipose tissue? and what adverse effects could it cause?
Niacin Adverse effects: - flushing - hyperuricemia - impaired glucose tolerance - hepatotoxicity
MYOPATHY with statins
which drug should be used if statins are contraindicated? how does it work?
Ezetimibe
inhibits absorption of cholesterol from small intestine
