Cardiac biomarkers Flashcards
1
Q
which troponin is the most specific for cardiac damage?
A
cTnI
2
Q
why does troponin help in late diagnosis?
A
cTnI stays elevated for 5 - 10 days
cTnT stays elevated for 5 - 14 days
3
Q
when do troponin levels rise and peak?
A
rise: 3 - 12hrs
peak: 24 - 48hrs
4
Q
DD of troponin
A
- cardiac surgery
- heart transplant
- defibrillation
- cardiomyopathy
- heart failure
- myocarditis
- supra ventricular tachycardia
5
Q
DD of CK-MB
A
- muscle trauma
- myocarditis
- muscle dystrophies
- physical exertion
- postoperative
- convulsions
- malignant hyperthermia
6
Q
What are the types of creatine kinase?
A
- CK-MB: heart
- CK-BB: brain
- CK-MM: skeletal muscle
7
Q
CK-MB after MI
A
begins to rise: 3-12hrs
peaks: 24hr
returns to normal: 2 - 3 days
8
Q
which biomarker is used for early diagnosis? and why?
A
Myoglobin (in cardiac & skeletal muscles)
it rises 1 - 3 hours after onset of ISCHEMIA
9
Q
myoglobin kinetics after MI?
A
- rises fast after MI (2 hrs)
- peaks at 6 - 8hrs
- returns to normal at 20 - 36hrs
10
Q
what are the types of LDH?
A
LDH-1: if elevated there’s damaged heart tissue
LDH-2: normally predominates
11
Q
LDH kinetics after MI
A
highest at 3 - 4 days
back to normal in 10 days
