Anti-TB drugs Flashcards
What are the first-line anti-TB drugs?
Rifampcin
Isoniazid
Ethambutol
Pyrazinamide
which drug causes auto induction and increases metabolism of Warfarin, phenytoin, and oral contraceptives?
Rifampcin
Which drug causes GOUT and what other adverse effects does it cause?
Pyrazinamide
arthralgia & myalgia
hepatotoxicity
Which drug causes optic neuritis and renal impairment?
Ethambutol
Isoniazid inhibits the metabolism of what drugs?
Warfarin
Carbamazepine
Phenytoin
Which drug should be taken with vitamin B6 and why?
Isoniazid because it could cause peripheral neuropathy
What is the only bacteriostatic drug?
Ethambutol
which drug inhibits protein synthesis by binding to 30s subunit of bacterial ribosomes?
Aminoglycosides (streptomycin, amikacin, capreomycin)
Which drug gets activated by KatG and what does it target?
Isoniazid
targets Inha & KasA
Which drug inhibits DNA dependent RNA polymerase and what adverse effects could be caused?
Rifampcin
red-orange secretions
flu-like symptoms
hepatotoxicity
which drug’s absorption is impaired with high fat meals?
Isoniazid
which drug inhibits arabinosyl transferase?
Ethambutol
Which drug inhibits fatty acid synthase in mycobacteria?
Pyrazinamide
Which drug causes convulsions and psychosis at high doses and has an equal concentration in the CSF and blood?
Isoniazid
Which drug causes ototoxicity and what could enhance it?
Aminnoglycoside
loop diuretics
Which drug causes tendinitis, and what other adverse effects could it cause?
Fluoroquinolones (LEVOFLOXACIN - MOXIFLOXACIN)
phototoxicity and tendon rupture
Which drug has good entry to inflamed tissue and causes nephrotoxicity?
Aminoglycosides
which drug prolongs action of theophylline and warfarin
Fluoroquinolones (LEVOFLOXACIN - MOXIFLOXACIN)
How do you treat latent TB?
3 months of isoniazid & rifampicin
OR
6 months of isoniazid
what type of TB is treated for 12 months with steroids?
meningeal TB
What type of TB takes 6 months to treat with the all first line drugs?
pulmonary TB
