Lipid-Lowering Drugs

Question 1

“-statin”s

Answer 1

Competitive inhibitors of HMG-CoA reductase; decrease mevalonate and cholesterol

Question 2

Cholestyramine

Answer 2

Bile acid resin; Prevent intestinal reabsorption of bile acids; liver must use cholesterol to make more

Question 3

Colestipol

Answer 3

Bile acid resin; Prevent intestinal reabsorption of bile acids; liver must use cholesterol to make more

Question 4

Colesevelam

Answer 4

Bile acid resin; Prevent intestinal reabsorption of bile acids; liver must use cholesterol to make more

Question 5

Ezetimibe

Answer 5

Prevent cholesterol absorption at small intestines brush border by inhibiting Niemann-Pick C1-like protein

Question 6

Gemfibrozil

Answer 6

Fibrate: Upregulates LPL, increasing triglyceride clearance; activates PPAR-a to induce HDL synthesis; most effective class in decreasing triglycerides

Question 7

Fenofibrate

Answer 7

Fibrate: Upregulates LPL, increasing triglyceride clearance; activates PPAR-a to induce HDL synthesis; most effective class at decreasing triglycerides

Question 8

Niacin

Answer 8

Inhibits lipolysis (hormone-sensitive lipase) in adipose; reduces hepatic VLDL synthesis; most effective agent for increasing HDL