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Pharmacology > CNS Drug Mechanisms of Action > Flashcards

CNS Drug Mechanisms of Action Flashcards

1
Q

Ethosuximide

A

blocks thalamic T-type Ca2+ channels

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2
Q

Benzodiazepines

A

Facilitate GABA(A) action by increased frequency of Cl- channel opening

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3
Q

Barbiturates

A

Facilitate GABA(a) action by increasing duration of Cl- channel opening, thus decreasing neuronal firing

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4
Q

Non-benzodiazepine hypnotics

A

Act via BZ1 subtype of the GABA receptor- reversed by flumazenil

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5
Q

Suvorexant

A

Orexin (hypocretin) receptor antagonist

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6
Q

Ramelteon

A

Melatonin receptor agonist, binds MT1 and MT2 in suprachiasmatic nucleus

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7
Q

Triptans

A

5-HT(1B/1D) agonists; inhibit trigeminal nerve activation; prevent vasoactive peptide release; induce vasoconstriction

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8
Q

Bromocriptine

A

Dopamine agonist

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9
Q

Amantadine

A

Increases DA release and decreases DA reuptake

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10
Q

Carbidopa

A

Blocks peripheral conversion of L-DOPA to DA by inhibiting DOPA decarboxylase

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11
Q

Entacapone

A

COMT inhibitor

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12
Q

Tolcapone

A

COMT inhibitor

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13
Q

Selegiline

A

MAO-B inhibitor

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14
Q

Benztropine

A

Antimuscarinic adjunct to improve tremor and rigidity

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15
Q

Trihexyphenidyl

A

Antimuscarinic adjunct to improve tremor and rigidity

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16
Q

Rasagiline

A

MAO-B inhibitor

17
Q

Tetrabenazine

A

Inhibit vesicular monoamine transporter (VMAT)–> decreases DA vesicular packaging and release

18
Q

Reserpine

A

Inhibit vesicular monoamine transporter (VMAT)–> decreases DA vesicular packaging and release

19
Q

Riluzole

A

Decreases glutamate excitotoxicity; ALS treatment

20
Q

Memantine

A

NMDA receptor antagonist

21
Q

Tacrine

A

AChE inhibitor

22
Q

Baclofen

A

Activates GABA(A) receptors at level of spinal cord, inducing skeletal muscle relaxation

23
Q

Cyclobenzaprine

A

Centrally acting skeletal muscle relaxant

24
Q

Pentazocine

A

Kappa-opioid receptor agonist and mu-opioid receptor weak/ partial agonist; analgesia

25
Q

Butorphanol

A

Kappa-opioid receptor agonist and mu-opioid receptor partial agonist; analgesic

26
Q

Tramadol

A

Very weak opiod agonist; also inhibits 5-HT and NE reuptake

27
Q

Methylphenidate/ Dextroamphetamine/ methamphetamine

A

Increases catecholamines in the synaptic cleft (esp NE and DA)

28
Q

Typical antipsychotics

A

Block D2 receptors (increase cAMP)

29
Q

Buspirone

A

Stimulates 5-HT1A receptors

30
Q

TCAs

A

Inhibit NE and 5-HT reuptake

31
Q

Bupropion

A

Inhibits reuptake of NE and DA

32
Q

Mirtazapine

A

Alpha 2 antagonist (increases NE and 5-HT release), 5-HT 2&3 antagonist; H1 antagonist

33
Q

Trazodone

A

Primarily blocks 5-HT2, alpha 1, and H1 receptors; weakly inhibits 5-HT reuptake

34
Q

Varenicline

A

Nicotinic ACh receptor partial agonist

35
Q

Vilazodone

A

Inhibits 5-HT reuptake; 5-HT1A receptor partial agonist

36
Q

Vortioxetine

A

Inhibits 5-HT reuptake; 5-HT1A receptor agonist and 5-HT3 receptor antagonist

Pharmacology (11 decks)

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