Lipid Biosynthesis

Question 1

Fatty acids are synthesised by

Answer 1

the sequential addition of 2 carbons which are derived from acetyl coA

Question 2

lipid biosynthesis occurs in the

Answer 2

cytosol

Question 3

lipid biosynthesis occurs in a multi-enzyme complex called

Answer 3

fatty acid synthetase

Question 4

which reductant is required in lipid synthesis

Answer 4

NADPH

Question 5

The fatty acid synthetase elongates fatty acids up to

Answer 5

palmitate (C18)

Question 6

before fatty acid synthesis can occur, …. must be transported from the …. to the ….

Answer 6

Acetyl coA
mitochondria
cytosol

Question 7

As acetyl coA can not move across membrane it must first be transformed into

Answer 7

citrate

Question 8

step 1 in synthesising fatty acids is the formation of …
Step 2 is the attachment of
step 3 is the condensation of … and … to form …
step 4 is reduction of … to
step 5 is reduction of ….. to …
Step 6 is reduction of … to …

Answer 8

Malonyl coA
Acyl carrier protein
Acetyl ACP, malonyl ACP, acetoacetyl ACP
Acetoacetyl ACP, D-3-Hydroxybutyryl ACP
D-3-Hydroxybutyryl ACP,  Crotonyl ACP
Crotonyl ACP, Butyryl ACP

Question 9

Total enegy requirement for producing palmitate is

Answer 9

7 ATP

14 NADPH