Limbic System

Question 1

What lesion can lead in anterograde amnesia?

Answer 1

Bilateral damage to the medial temporal lobes including the hippocampus
*loss ability to acquire new information

Question 2

Features in klüver-bucy syndrome, and where is the lesion?

Answer 2

• placidity, psychic blindness, hypermetamorphosis, oral behavior increased, hypersexuality and loss sexual preference, anterograde amnesia
• bilateral amygdala and hippocampus

Question 3

Cause korsakoff syndrome (psychosis)? What precedes its onset? Signs and symptoms

Answer 3

• alcoholics ▶️ thiamine deficiency. Lesions at mamillary bodies and dorsomedial nuclei thalamus
• acute thiamine deficiency previous Wernicke encephalopathy ▶️ ocular palsies, confusion (dementia), gait ataxia ⏭ Wernicke-korsakoff syndrome
• anterograde and retrograde amnesia, confabulations

Question 4

Earliest structure affected in Alzheimer disease?

Answer 4

Hippocampus and temporal lobe (most severe too)

*learning and memory