LFT

Question 1

What happens when there is a blockage in intra/extra hepatic ducts?

Answer 1

conjugated/unconjugated bilirubin builds up in blood

Question 2

is conjugated more/less water soluble than unconjugated?

Answer 2

more

Question 3

What happens when there is a blockage in the extrahepatic duct?

Answer 3

build up of soluble conjugated bilirubin, pass through the blood into the kidney. Patient has bilirbuinurea, bilirubin in urea

Question 4

Does alkaline phosphatase have a high or low specificity for cholestasis

Answer 4

Low

Question 5

Any blockage in intra/extra hepatic area increase ….which is known as the condition……

Answer 5

alkaline phosphatase

cholestasis

Question 6

what are the 3 things that increase ALK PHOSPHATASE?

Answer 6

1- Cholestasis
2-pregnancy
3-bone disease-growth

Question 7

What is another test besides alk phosphatase to confirm cholestasis?

Answer 7

gamma glutamyl transferase

Question 8

How does one confirm cholestasis after through GGT test?

Answer 8

increase in GGT is only a sign of cholestasis and not bone growth (the process of elimination

Question 9

What is gilberts disease?

Answer 9

autosomal dominant-increase in total bilirubin due to inexpression of GGT enzyme which is used to convert unconjugated -> conjugated bilirubin

Question 10

What are the 3 enzymes involved in LFT?

Answer 10

ALT/AST

Alkaline phosphatase