levetiracetam, zonisamide

Question 1

levet indications epilepsy

Answer 1

focal seizures with or without secondary generalisation
myoclonic and tonic clonic

Question 2

levet cautions

Answer 2

RF for QT interval porlongation

Question 3

levet interaction MTX

Answer 3

Levetiracetam decreases the clearance of Methotrexate. Manufacturer advises monitor Levetiracetam and Methotrexate concentrations.

Question 4

most levet interactions are to do with

Answer 4

CNS depression and sedation

Question 5

use of levet in pregnancy

Answer 5

Clinical response should be monitored during pregnancy—plasma concentrations decrease during pregnancy (by up to 60% in the third trimester).

Question 6

zonisamide indications

Answer 6

focal seizures with or without secondary generalistion

Question 7

what to be aware of in children taking zonisamide

Answer 7

Avoid overheating and ensure adequate hydration especially in children, during strenuous activity or if in warm environment (fatal cases of heat stroke reported in children).

Question 8

zonisamide interaction with AED drug

Answer 8

topiramate potentially increases the risk of overheating and dehydration when given with Zonisamide. Manufacturer advises avoid in children.

Question 9

name the drugs that potentially increases the risk of overheating and dehydration when given with Zonisamide. Manufacturer advises avoid in children.

Answer 9

acetazolamide, climpramine, haloperidol, hydroxyzine, imipramine, oxybutynin, topiramate