Epilepsy syndromes

Question 1

Dravet syndrome - 1st line

Answer 1

SV for ALL pt including females because of severity of syndrome and lack of evidence for other effective 1st line options

Question 2

If SV for Dravet syndrome or Lennox Gastaut syndrome is started or continued in females who are able to have children, ensure …

Answer 2

• potential risks and benefits of treatment are discussed
• likelihood of pregnancy is considered
• PPP put in place if appropriate

Question 3

1st line adjunctive therapy for Dravet syndrome if monotherapy with SV unsuccessful

Answer 3

TRIPLE therpay with clobazam + stiripentol

Question 4

2nd line adjunctive therapy for Dravet syndrome if monotherapy with SV unsuccessul, then 1st line adjunctive triple therapy (SV + Clobazam + Stiripentol) unsuccessful

Answer 4

cannabidiol + clobazam + SV in certain pt

Question 5

who should be involved in decisions regarding the treatment of Dravet syndrome and Lennox-Gastaut syndrome

Answer 5

neurologist with expertise in epilepsy

Question 6

1st line for Lannox-Gastaut syndrome

Answer 6

SV for ALL pt, including females, due to severity of syndrome and lack of evidence for other 1st line options

Question 7

2nd line monotherapy or adjunct for Lenox Gastaut syndrome

Answer 7

if 1st line mono with SV unsuccessul,
consider lamot as 2nd line mono or adjunct