gaba, pregab, cannabidiol

Question 1

what type of seizure is gaba used for

Answer 1

focal seizures with or without secondary generalisation
for gabapentin

Question 2

risk of abuse and dependence with these drugs

Answer 2

gaba and pregab

Question 3

risk of respiratory depression with these drugs

Answer 3

gaba and pregab

Question 4

main interactions with gaba and pregab are to do with

Answer 4

CNS depressant and sedation

Question 5

what to monitor in gaba pt

Answer 5

signs of abuse

Question 6

what seizure is pregab used for

Answer 6

focal seizures with or without secondary generalisation

Question 7

gaba and pregab - risk of resp depression. dose adjustmnets may be necessary in pt at higher risk e.g. (3)

Answer 7

with compromised respiratory function, respiratory or neurological disease, or renal impairment;
taking other CNS depressants (including opioid-containing medicines);
aged older than 65 years.

Question 8

treatment cessation pregab

Answer 8

Avoid abrupt withdrawal (taper over at least 1 week).

Question 9

cannabidiol use in epilepsy - what seizures

Answer 9

lennox gastaut syndrome (adjunct with clobazam)
dravet syndrome (adjunct with clobazam)

Question 10

cannabidiol and valproate interaction

Answer 10

Cannabidiol increases the risk of increased ALT concentrations when given with Valproate. Manufacturer advises avoid or adjust dose.

Question 11

cannabidiol monitoring

Answer 11

LFTs: baseline, 1 month, 3 months, 6 months, periodically thereafter

more freq in raised ALT or AST or taking valproate

Question 12

cannabidiol CD schedule

Answer 12

5, epidoxylex