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Humane fysiologie > Lever 4-5-23 > Flashcards

Lever 4-5-23 Flashcards

1
Q

Cell types

A

Hepatocyten
CHolangiocytes
Kupffer cellen
Stellate cells

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2
Q

Sinusoid

A

Specialized cappilaries
gebied tussen endotheel cellene n hepatocyten

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3
Q

Kupffer cells

A

“macrofaag” van de lever in sinusoids

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4
Q

Stellate cells

A

Vitamine A opslag
Kan worden omgezet tot myofibroblast -> fibrose (bindweefselvorming)

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5
Q

Hoeveel bloed door de lever per dag?

A

10 L/min
14400 L/dag

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6
Q

Cholangiocyten

A

vormen bile duct (galgang)

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7
Q

Functie counter current flow

A

Stoffen zo goed mogelijk uitscheiden
concentratie gradient altijd zo optimaal mogelijk

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8
Q

Summary levr funtie

A
  • Detoxification & drug metabolism
  • Koolhydraat metabolism & glucose homeastase
  • Lipid metabolism & homeostase
  • Blood clotting
  • regulation blood volume & pressure
  • bile production
  • Vitamine storage (A,D,E,K,B12)
  • Iron storage (production hemoglobin)
  • Hormone secretion & metabolism
  • Immune function
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9
Q

Components bile

A
  • bile salts
  • Bilirubin
  • Cholesterol
  • Phospholipids
  • Water
  • Elektrolytes
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10
Q

Cholesterol

A

wordt omgezet tot galzouten
eigen productie en dieet
Statine remt productie

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11
Q

Functie binnen zone rond central vein in lobule

A
  • Aminozuur afbraak
  • Urea synthese
  • Gluconeogenese
  • Glycogeen synthese
  • Citrate cycle
  • respiratory chain
  • Fatty acid oxidation
  • oxidation protection
  • cholesterol synthesis
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12
Q

Funcites buiten zone bij portal vein in lobule

A
  • glutamine synthese
  • glycolyse
  • glycogeen synthese
  • lipogenesis
  • biotransformatie
  • detoxificatie
  • bile acid synthesis
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13
Q

Cytochrome P450 betrokken bij

A

drug metabolisme

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14
Q

Paracetamol toxisch door omzetting van

A

CYP’s

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15
Q

ammonia afbraak

A

Hoge concentratie: urea (in blauwe zone bij CV)
Lage concentratie: glutamine

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16
Q

NTCP

A

enzym dat galzouten filtert uit portal vein

17
Q

Summary lever functie in glucose huishouding

A
  • Glucogenolysis: glucogeen > glucose
  • Glucogeneosis: syntehse glucose uit non- koolhydraten
  • Glycolyse
  • Insulin & glucagon
  • Lactate handling: lactate -> glucose
  • detofxification
18
Q

Liver disease

A
  • Alcohol
    -Non-Alcoholic Fatty Liver Disease (NAFLD)
  • Viral hepatitis
  • Immune mediated (cholesterol) disorders
  • Drug-induced liver injury
  • Genetic deficiences

Humane fysiologie (10 decks)

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