Endocrinologie 6-5-23 Flashcards
Verschillen zenuw en endo stelsel
goodnotes
Exocrine gland
Produceert geen hormonen: speeksel etc
heeft ducts
Endocrine gland
Produceerd hormonen
heeft geen ducts
Hormones
Long distance chemical signal that travels in blood/lymph
Autocrines
Short distance chemicals.
Effect op dezelfde soort cellen als die de stof secreren.
Paracrines
Short distance.
Act locally, but affect different cel types
3 type of endocrine glans stimuli
- Neuro
- Altered level of ion/nutrient
- Hormone
Cell respons depends
- Heeft de cell de receptor?
- Concentratie
- Aantal receptoren
- Affiniteit
Verschillen vet/water oplosbaar
Vet:
- Steroids & throid
- No vesicles
- Bound to plasma protein in blood
- Long half-life in blood
- Receptor in cel
- Activate genes > synthesis proteins
Water:
- Aminozuur (behalve thyroid)
- Vesicles
- vrij in bloed
- Short half-life in blood
- Receptor in membraan
- Activate second messenger system
Permissiveness
Interaction
Hormoon kan effect niet compleet uitvoeren zonder bijzijn van ander soort hormoon
Synergism
2 hormonen hebben hetzelfde effect die geamplificeerd wordt
Antagonism
hormonen hebben tegengestelde werking
Posterior pituitary gland
Actiepotentialen van hypothalamus
Oxytocin
ADH
Anterior pituitary gland
Hypothalamic hormone stimuli
Growth hormone
Thyroid-stimulating hormone
Adrenocorticotopic hormone
Follicle-stimulating hormone
Luteinizing hormone
Prolactin
Oxytocin
Posterior pituitary
Stimulated by hypothalamus in respons to stretching of uterine cervix or suckling on breast
inhibited by lack of stimuli
Antidurectic hormone (ADH)
Posterior pituitary
Stimulated by impluses hypothalamus in respons to increased concentration in blood/decreased blood volume. Or pain, low bloodpressure
Inhibited by good hydration (or alcohol)
stimlates the kidneys to resorb water back into blood
Thyroid-stimulating hormone (TSH)
Anterior pituitary
Stimulated by Thyrotropin-releasing hormone
Inhibited by feedback inhibition & Growth hormone-inhibiting hormone
Stimulates thyroid glands to release thyroid hormones
ADrenocorticotropic hormone (ACTH)
Stimulated by corticotropin-releasing hormone (fever, hypoglymia)
inhibited by feedback inhibition by glucocorticoids
Stimulates release of glucocorticoids and androgens
Follicle stimulating hormone (FSH)
Stimulated by Gonadotropin-releasing hormone
inhibited by inhibin & estrogens/testosterone
Stimulates follicle maturation, production estrogens & sperm production
Luteinizing hormone (LH)
Stimulated by Gonadotropin-releasing hormone
Inhibited by feedback from estrogens & progesteron / testosterone
Stimulates ovulation, estrogen production & testosterone production
Prolactin (PRL)
Stimulated by decreased prolactin-inhibiting hormone, release of estrogens, breast-feeding
inhibited by prolactin-inhibiting hormone (PIH) (dopamine)
Stimulates lactation
