Leukopenia- P

Question 1

What is the cell marker of hematopoietic stem cells?

Answer 1

CD34+

Question 2

What is a normal WBC?

Answer 2

4.5-11k/uL

Question 3

What is leukopenia?

Answer 3

Less than 4.5k/uL WBC’s

Question 4

What is leukocytosis?

Answer 4

Greater than 11k/uL WBC’s

Question 5

Drug toxicity and severe infection are 2 common causes of what?

Answer 5

Neutropenia

Why

1. Chemo and alkylating agents
2. Increased movement of neuts into the tissues

Question 6

What is the common treatment for neutropenia?

Answer 6

GM-CSF or G-CSF to boost granulocytes

Question 7

What are the causes of lymphocytopenia?

Answer 7

1. immunodeficiency (SCID, HIV and DiGeorge)
2. High cortisol
3. AI destruction (SLE)
4. Whole body radiation
5. sepsis/postop

Question 8

Failure for the 3rd and 4th pharyngeal pouch to develop results and what missing and what is the dz called?

Answer 8

Thymus

Called DiGeorge Syndrome

Question 9

What does increase cortisol in the serum do the lymphocytes and what can cause this?

Answer 9

1. Exogenous steroids
2. Cushing syndrome

• causes apop of lymphocytes

Question 10

What is the most sensitive cell in the body to radiation?

Answer 10

Lymphocytes

Question 11

What besides drug toxicity and sepsis can cause neutropenia? What levels is considered this?

Question 12

What cause and what levels are considered eosinopenia?