Infectious mononucleosis- P Flashcards
EBV and less commonly CMV cause what dz, AKA kissing dz?
Infectious mononucleosis
IM cause lymphocytic leukocytosis of what particular cell and in what age group of people?
CD8+ T cells
Teens
EBV primarily infects what areas or cells?
- Oropharnx–> pharngitis
- Liver–> hepatomegaly with hepatitis–> means elevated liver enzymes
- B cells
Increase in CD8+ T-cells leads to what clinical findings?
- LAD
- Splenomegaly
- Lymphocytic leukocytosis= high WBC–> see atypical cells
How would increase in CD8+ T cells found in serum cause LAD?
T cell hyperplasia in the LN
- Paracortex
What happens in the cortex of the LN?
B- cell proliferation
How does T cell hyperplasia cause splenomegaly? Where in the spleen is this found?
Hyperplasia in the Periarterial lymphatic sheath (PALS)
- White pulp is where its found
- dense blue hue around arteries of spleen
How does the monospot test work and what is it used to screen? Timeline for best outcome?
Screens for mono
- Detects IgM Ab’s that cross react with horse of sheep RBCs
- after 1 week of infection
- negative test suggest CMV
What are heterophile Ab’s?
other loving
- Our Ab’s bind to cells of another animal at high affinity
The monospot test is a screening test. Is this definitive? If not what test is definitive for EBV IM?
No its just a screen
- Dx–> serologic testing for EBV viral capsid Ag
Im purposes some complications. What should be warning our patients about after leaving the clinic?
- Increase risk for splenic rupture- no contact sports for 1 MONTH
- Rash if taking cilins
- Lays dormant in B cells
EBV dormancy in B cells increases risk of what? What dz in particular can make an individual extremely susceptible?
Recurrence and B cell lymphoma
- immunodeficient individuals (HIV)
