Chronic Leukemia-P

Question 1

What are the basic principles of chronic leukemia?

Answer 1

Neoplastic proliferation of MATURE circulation lymphocytes

• increased WBC
• usually insidious in onset
• older adults

Question 2

What is CLL?

Answer 2

Proliferation of Naive B cells that Co-express CD5 and CD20

- MOST COMMON Leukemia overall

Question 3

What is a common blood smear finding of CLL?

Answer 3

Smudge cells

- looks like splattered cells on the blood smear

Question 4

What CLL has involvement with the lymph nodes what is it called?

Answer 4

Small lymphocytic lymphoma

- presents with LAD

Question 5

What are the 3 common complications found with CLL?

Answer 5

1. hypogammaglobinemia
2. AIHA
3. Transform into diffuse Large B cell lymphoma

Question 6

What is the most common cause of death with someone with CLL?

Answer 6

Infection due to decreased Gamma globulin

Question 7

Someone with CLL comes in with splenomegaly and LAD what is the likely cause?

Answer 7

Complication of CLL transforming into large B cell lymphoma

Question 8

Neoplastic proliferation of Mature B cells Characterized by hairy cytoplasmic processes is known as what?

Answer 8

Hairy Cell Leukemia

Question 9

Cells in HCL are positive for what?

Answer 9

Tartrate-resistant acid phosphatase (TRAP)

Question 10

Hairy cells in HCL are thought to be trapped in the red pulp of the spleen and the bone marrow what sort of consequences does this lead to?

Answer 10

• Splenomegaly
• Marrow fibrosis (Dry Tap on Bm aspirate)
• NO LAD because hairy cells trapped in BM and Red pulp of spleen.

Question 11

What is the desired treatment of HCL and what is its MOA?

Answer 11

2-CDA (Cladrabine)

- Adenosine deaminase inhibitor which cause adenosine to build up at toxic levels in the neoplastic B cells

Question 12

What is Adult T cell Leukemia/lymphoma (ATLL) and what is it association?

Answer 12

Neoplastic prolif of mature CD4+ T cells

• ass. with HTLV-1
• most common in Japan and Caribbean

Question 13

What are the clinical symptoms of ATLL?

Answer 13

1. Rash
2. LAD
3. hepatosplenomegaly
4. Lytic bone lesions with

Question 14

Of those clinical symtomes what distinquishes ATLL from Multiple Myeloma?

Answer 14

The rash

Question 15

What is Mycosis Fungiodes?

Answer 15

Neoplastic prolif of CD4+ T Cells that infiltrate the skin 
Produces 
- Skin rash 
- Plaques
- Nodules

Question 16

When aggregates of neoplastic cells develop in the epidermis it is called what and what dz is it ass.?

Answer 16

Pautreier Microabscesses

- Mycosis Fungoides

Question 17

If dz spread to the blood what is its called and what is found on a blood smear of an individual with Mycosis Fungoides?

Answer 17

• Sezary syndrome

- Sezary cells which are characteristic lymphocytes with cerebriform nuclei