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MEDICINA 2 > Leucemia > Flashcards

Leucemia Flashcards

1
Q

LLA precursor B

A

CD19, 22, 79a, HLA-DR

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2
Q

LLA precursor T

A

CD7, 3c, 3m -/+ débil

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3
Q

Tto LLA

A

Prefase: 5-7 días CTC: predni, dexa
Inducción: 4-8ss QT
Consolidación: 0.5-1 año QT
Mantenimiento: 2 años

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4
Q

LMA ↑ riesgo

A

↑3 alt. cromosómicas, monosomal, Philadelfia

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5
Q

Tto LMA

A

Inducción: remisión, quedan cel. leu
QT Consolidación: eliminar enf. residual, NO detección cel leu
QT/ TPH Intensificación: 3 ciclos de QT Oo TPH, curación

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6
Q

LMC def

A

Producción desregulada de granulocitos maduros con nivel de diferenciación normal

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7
Q

LMC dx incidental en % de cc

A

40, 10-15% en enf acelerada o fase blástica

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8
Q

Px % en fase crónica LMC

A

85%

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9
Q

Tto LMC

A

Inhibidores de tirosin kinasa: Imatinib
TCH
Agentes citotóxicos

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10
Q

Inmunofenotipo en LLC

A

CD19 +, CD5+, CD23+, CD20+, CD22-

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11
Q

Signo + fcte en LLC

A

Linfoadenopatía (50-90%)

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12
Q

Dx de LLC

A
  • Linfocitosis en SP ↑5mil B clonales x min 3 meses
  • Citometría CD19, 20, 23, 5
  • Infiltración clonal ↑30%
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13
Q

Mal pronóstico en LLC

A

Mutación TP53 y/o BIRC3
Sobrevida a 5 años de 51%
Sobrevida a 10 años de 29%

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14
Q

Inicio tto LLC

A
  • Insuf. medular progresiva: citopenia
  • Esplenomegalia
  • Adenopatía voluminosa
  • Linfocitosis + 50%
  • 1 de síntomas B
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15
Q

Opciones tto LLC

A
  • Análogos de purina: fludarabina
  • Agentes alquilantes: ciclosfos
  • Ac monoclonales: ritu,
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16
Q

Factor de riesgo para LLC

A
  • Radiación ionizante
  • Agente naranja
  • Ant. fam 2 a 4 veces +
17
Q

A qué edad afecta + LLC

A

AM: 65-70 años

18
Q

Clínica de LMC

A

Esplenomegalia, saciedad precoz, dolor en cuadrante superior izq

19
Q

Síntomas de progresión de LMC

A

Fiebre, ↓ peso, ↑ dosis [F] para enf., dolor óseo y articular, hemorragia, trombosis e infecc

MEDICINA 2 (16 decks)

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