Lesson E2 - Over-the-Counter (OTC) Drugs Flashcards
Over-the-counter (OTC) drugs are sold to the general public without a physician’s prescription
based on the premise that the general public are able to
diagnose mild symptoms and to select appropriate agents to treat these symptoms.
OTCD
Any drug that can be purchased without a physician’s prescription. The general public often
does not consider these agents as drugs.
The sale of OTC drugs is controlled by a section of the Food and Drug Act. The Act controls
safety, efficacy, advertising and sale of these products. All OTC drugs must undergo
rigid safety assessment.
Acetylsalicylic acid (ASA):
This compound has been widely used for well over a century. The compound possesses
analgesic (reduces pain), antipyretic (reduces fever), and anti-inflammatory (reduces
inflammation) properties. In appropriate doses, the drug is effective for pain, fever and
inflammation.
The mechanism of action of ASA for all three effects is that it inhibits synthesis of
prostaglandins, endogenous substances which enhance the mediation of pain, fever and
have a role in inflammation.
The major toxicity of ASA is gastric irritation which occurs in
2% of the population
ASA
breaks down the mucosal protective barrier in the stomach and leads to irritation and increased
bleeding. This is a serious problem when ASA is taken chronically in high doses. Enteric
coated ASA tablets will reduce the gastric irritation, but the onset of action is slow and are not
useful for relief of pain but are useful in
chronic inflammation
ASA is associated with Reyes
syndrome in children when it is given during
fever
An additional use for ASA is in the prevention of strokes and myocardial infarcts. Low dose
ASA has been shown to reduce the risk of these serious diseases. The mechanism is to inhibit
platelet aggregation and hence
clot formation.
Acetaminophen was first introduced into therapeutics in 1877 but did not gain popularity until
the 1950’s. Acetaminophen is an analgesic and antipyretic, and is equal in efficacy to ASA for
these two effects. Unlike ASA, acetaminophen is not
anti-inflammatory.
The mechanism of action is similar to that of ASA, i.e. it inhibits prostaglandin synthetase, the enzyme responsible for the
formation of postaglandins.
At therapeutic doses, acetaminophen is very well tolerated; it does not cause
gastric irritation.
Ibuprofen is a non-steroidal, anti-inflammatory agent which appeared as an OTC product in the
early 1990’s. Ibuprofen is an effective analgesic and antipyretic as well as an
anti-inflammatory
compound.
The mechanism of
action of ibuprofen is a reversible
inhibition of the synthesis of prostaglandins.
Naproxen
This recent addition to the OTC group of analgesics, is an effective analgesic, antipyretic and
anti-inflammatory agent. It may well emerge as the most effective OTC anti-inflammatory agent
available. It is an inhibitor of
prostaglandin synthesis