Lesson A1 - Pharmacology Flashcards
In ancient societies medicine men acted as…
Physicians + Priests
Medical practice was distorted by
Religion + Magic
Why did religion use to use intoxicating substances
To try and communicate to God
How did people use to try and communicate with God
Using intoxicating substances to by altering the state of consciousness
2 plants that use to be used to alter the state of consciousness to try and communicate with God and where were they from
- Psilocybe mushroom ( Mexico)
- Peyote cactus ( North America)
Psilocin comes from what plant and what was it used for
- Psilocybe mushroom
- Used to try and communicate with God in the past
What plant contains mescaline and where is it from and what was it’s purpose
- Peyote cactus ( North America)
- Used to try and communicate with God in the past by altering the state of consciousness
Who said the following quote “ all substances are poisons. There is none which is not a poison. The right dose differentiates a poison and a remedy”
- Paracelsus
- Swiss physician (16th century)
Who is Paracelsus
- Swiss physican in the 16th century
- He said “ all substances are poisons. There is none which is not a poison. The right dose differentiates a poison and a remedy”
What were the purpose of ordeal trials
Identify sorcerers
What are the 2 things that can happen in an ordeal trial
- People vomited → and didn’t die (were not classified as sorcerers)
- People who didn’t vomit → (they were classified as sorcerers)
What is an ordeal trial?
- People of the tribe gathered in a circle and was given poison from a traditional healer to see who were sorcerers (people who could be the cause of epidemics and bad harvest)
What is it called when people gather in a circle and are given poison (usually done in West and Central Africa and Madagascar)
Ordeal trials
What is this called
- People vomited → and didn’t die (were not classified as sorcerers)
- People who didn’t vomit → (they were classified as sorcerers)
ordeal trial
Many drugs are derived from __________
Poisons
A poison that treats glaucoma
Physostigmine
What is Physostigmine used to treat?
Glaucoma
Where is Physostigmine derived from?
Calabar bean
The Calabar bean is the plant used to make what drug? What does this drug treat?
- Physostigmine
- Treats glaucoma
Natives dipped arrows in _____
Curare (poison)
What drug caused animal paralysis+death
- Curare
- From natives who dipped their arrows in it
What does Curare cause?
Animal paralysis + death
Nerves dealing with skeletal muscles relieve what?
Acetylcholine
What is released from nerve endings
Acetylcholine
_______ combines with receptors causing the muscle to contract
Acetylcholine
What does Acetylcholine do and cause?
Combines with receptors causing the muscle to contract
How does Curare interfere with Acetylcholine?
Combines with receptors instead of the usual acetylcholine
What combines with receptors instead of the usual Acetylcholine?
Curare
_________ prevents _______ from combining with muscle which prevents ________
Curare, Acetylcholine, Muscle contraction
_______ valuable drug to a skilled anaesthetist
Curare
Curare is a valuable drug to a __________
Skilled anaesthetist
Curare is a ______ that a _________ can use
Poison, killed anaesthetist
Giving small doses of _______ to a patients causes their muscles to relax allowing the surgeon to do better work
Curare
What does small doses of curare allow
Causes patients muscles to relax which allows the surgeon to do better work
Drug that let’s a surgeon do better work
Curare
_______ is a fungus that grows on the ears of rye
Ergot
What is Ergot?
A fungus that grows on the ears of rye
Rye causes ________ which are ______ to humans
Alkaloids, toxic
Middle ages ______ was mixed with ______ and found it’s way into bread
Ergot, Rye
What happened when Ergot was mixed with Rye?
Terrible epidemics = 250 years ago = 20,000 died in one region in Russia
What are the 3 symptoms of ergot poisoning?
- Burning in the limbs (Holy Fire or Anthony’s fire)
- Constriction of blood flow (toes/limbs starved of blood supply = limbs become black = gradually died and fell off
- Mental frenzy/Hallucinations + Convulsions
Some compounds of ________ resemble ______
Ergot, LSD
LSD is based of what?
Structure of ergot alkaloids
What could the following symptoms be caused by? (toes/limbs starved of blood supply = limbs become black = gradually died and fell off
- Ergot Poisoning
- Constriction of blood flow
Holy fire or Anthony’s fire is caused from what?
Ergot Poisoning
What causes burning in the limbs?
Ergot Poisoning
What causes constriction of blood flow?
Ergot Poisoning
What causes Mental frenzy/Hallucinations + Convulsions?
Ergot Poisoning
Ergot Poisoning
Ergotamine
________used in the treatment of migraines
Ergotamine
__________ are caused by the pulsation of __________ which carry blood to the head
Migraines, Blood vessels
How does ergotamine work
- Constricts blood flow
- Constricts blood vessels which carry blood to the brain and reduce the amplitude of the pulsation of these blood vessels
Ergotamine _____(3 words)__________ and reduces the _________ of the _______ of these blood vessels
Constricts blood vessels, amplitude, pulsation
Medical specialty dealing with the care of all women’s reproductive tracts and their children during pregnancy (prenatal period), childbirth and the postnatal period.
Obstetrics
Obstetrics
Medical specialty dealing with the care of all women’s reproductive tracts and their children during pregnancy (prenatal period), childbirth and the postnatal period.
Ergonovine is used in what type of medicine
Obstetrics
___________ helps the uterus contract forcefully and helps stop bleeding
Ergonovine
What does Ergonovine do?
Helps the uterus contract forcefully and helps stop bleeding
Main use of Ergonovine
Arrest bleeding after childbirth
Ergonovine was used to _________ to speed up_________
contract the uterus, delivery
________ is no longer used to contract the uterus, speed up delivery and arrest bleeding after childbirth because it is too dangerous
Ergonovine
Why is Ergonovine no longer used
Too dangerous
Who classified drugs according to taste (Botanicals + Animal products) and what was the time period?
- 2700 BC
- Shen Nong
___________ classified drugs according to taste (Botanicals + Animal products) in 2700 BC
Shen Nong
In 2700 BC Shen Nong classified drugs according to ______ ( ________+_______)
Taste, Botanicals, Animal products
What was Ma Huang used for?
Fever, Cold, Influenza
_______ is classified as a medium drug and used to treat _______(3 things)______
- Ma Huang
- Fever, Cold, Influenza
What drug is isolated from Ma Huang? What is is used to treat?
Ephedrine, Asthma as a decongestant
Ephedrine is isolated from _______ and used to treat ________
Ma Huang, Asthma as a decongestant
Chinese traditional medicine still uses _________
Plants and animal products
Plants and animal products are used in what type of medicine?
Tradition Chinese Medicine
What type of medicine believed that milk from a mother that gave birth to a healthy child would heal a sick child
Early Egyptian Medicine
What would milk from a mother who gave birth to a healthy child do?
Heal a sick child
What does Early Egyptian medicine believe would heal a sick child
Milk from a mother who gave birth to a healthy child
Who is Ebers Papyrus?
Egyptian writing which was essentially a textbook of drug use for physicians
_____________ were Egyptian writings which were essentially a textbook of drug use for physicians
Ebers Papyrus
What type of drugs did the Egyptian writings, Ebers Papyrus contain?
Purgatives
_________ were contained in the Ebers Papyrus writing
Purgatives
________ drugs used to cause bowel movements
Purgatives
What are purgatives
Drugs used to cause bowel movements
Give 3 examples of purgatives
Caster oil, Figs, Senna
Caster oil, Figs, Senna are examples of _________
Purgatives
_______ containing products are still available today
Senna