Lesson 4 Flashcards
Caused by either RHO or ABO incompatibility
Hemolytic Disease of Newborn
There’s a problem in the Rhesus Factor
RHO Incompatibility
There’s a problem in the blood group
ABO Incompatibility
Mothers produce _____ to destroy the RBCS of fetus
Antibodies
Hemolysis results in ???
Fetal Anemia
Hyperbillirubinemia
Occurs when frtal red bloods which possess an antigen that the mother lacks
Hemolytic Disease
Crosses the placenta into maternal circulation, where they stimulate antibody production
Hemolytic Disease
The antibodies return to the fetal circulation and result in ________
RBC destruction
Called as the continue abortion; 3 or more pregnancy loss due to RH Incompatibility
Habitual Abortion
Differential Diagnosis of Hemolytic Anemis in Newborn Infant
Isoimmunizatiln
RBC enzyme disorder
Hemoglobin synthesis disorder
RBC membrane abnormalities
Hemangiomas
Acquired condition
Types of Isoimmunization
ABO Incompatibility
RH Incompatibility
Occurs when maternal blood type is O and fetus is blood type A, B, AB
ABO Incompatibility
Most common blood type
Type A
Most serious blood type
Type B
Rare blood type
Type AB
It destroys fetal RBCS
Maternal antibodies
Generally less severe than RH disease
ABO Incompatibility
Laboratory findings for ABO Incompatibility
Microspherocytosis
MCV <95, microcytic for newborn
Direct Coombs Test is often weakly +
Blood prep for a mother with ABO Incompatibility
Type O Rh Negative packed RBCs
ExTx means
Partial Exhange Transfusion
Anticipate need for later ExTx for __________
Hyperbillirubinemia
What should you give if a baby is preterm
Surfactant
It used for immediate drainage of hydropic fluid
Catheters
Assisted ventilation with oxygen. If ventilation is difficult, drain _________
Pleural and Ascitic Fluid
In paracentesis, take care to avoid puncturing the
Enlarged lived abd spleen
Insert _______ and _____, to immediately measure blood pressures, arterial ph, blood gas tensions, hematocrit, blood sugar
Umbilical arterial
Venous Catheter
Essential for effective resuscitation
Correct anemia
Do not infuse packed RBC or blood through __________ because of risk of damage to spinal cord from emboli
UAC
Due to CA++ binding by citrate
Hypocalcemia
It particularly after ExTx, due to dextrose load from anticoagulant of donor blood and hyperinsulinism in HDN
Hypoglycemia
It occurs especially with older units of blood
Hyperkalemia
Associated with inadequate warming of blood
Hypothermia
A protein antigen present on the surface of some people’s RBC (Rh+)
RH (D) factor
It is the exposure of Rh- blood to Rh+ blood resulting to production anti-Th abs
Rh Sensitization/ Rh isoimmunization
Rh sensitization can occur through
Sensitization from previous pregnancy
Inadequate response to prophylaxis
Incompatible blood transfusion
Rh Sensitization can occur thru:
Senstization from previous pregnancies
Inadequate response to prophylaxis
Incompatible blood transfusion
Insignificant amount of antibodies are formed during pregnancy, thus ____ baby is not greatly affected
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