Lesson 3: CELL STRUCTURE OF MATURE PLATELET, PLATELET KINETICS

Question 1

It is also known as a “Fluffy coat”

Answer 1

Glycocalyx

Question 2

these surrounds the cellular membrane of the
platelet externally.

Answer 2

Glycocalyx/Fluffy coat

Question 3

It is unique among the cellular components of the blood.

Answer 3

Glycocalyx

Question 4

It is composed of plasma proteins and carbohydrate molecules that are related to the coagulation, complement, and fibrinolytic systems.

Answer 4

Glycocalyx

Question 5

It provides structure of the platelet to maintain its discoid shape

Answer 5

MICROFILAMENTS & MICROTUBULES

Question 6

Where are MICROFILAMENTS & MICROTUBULES located?

Answer 6

located directly beneath the cell membrane of platelet

Question 7

maintains the position of the organelles

Answer 7

Microfilaments and microtubules

Question 8

Cellular Structure of a mature platelet is composed of what?

Answer 8

Granules and Other cytoplasmic constituents

Question 9

What are the OTHER CYTOPLASMIC CONSTITUENTS of a mature platelet?

Answer 9

Contractile proteins, Glycogen, and Enzymes of the glycolytic and hexose pathways

Question 10

What is the most abundant granule?

Answer 10

Alpha Granules

Question 11

What does Alpha Granules contain?

HVPPFBT

Answer 11

1. Heparin-neutralizing platelet factor 4 (PF4)
2. beta-thromboglobulin
3. platelet-derived growth factor
4. Platelet fibrinogen
5. fibronectin
6. von Willebrand factor (vWF)
7. thrombospondin

Question 12

Delta granules are also known as…

Answer 12

Dense granules

Question 13

Delta granules contain…

CASA

Answer 13

1. Calcium
2. ADP
3. Serotonin
4. ATP

Question 14

These store hydrolase enzymes

Answer 14

Lysosomes

Question 15

Contractile proteins include what?

Answer 15

actomyosin, myosin, and filamin

Question 16

actomyocin is also known as

Answer 16

thrombosthenin

Question 17

How many platelets does an average megakaryocyte produce?

Answer 17

1000 to 2000 platelets

Question 18

What is the marrow transit time / maturation period of megakaryocytes?

Answer 18

FIVE DAYS

Question 19

Platelets initially enter what organ?

Answer 19

The spleen

Question 20

Platelets initially enter the spleen & remains for how many day/s?

Answer 20

2 days

Question 21

Platelets are in either the _________ or the __________?

Answer 21

circulating blood, active splenic pool

Question 22

Approximately 2/3 of the total number of platelets are in the spleen that free exchange with the general circulation

True or False

Answer 22

FALSE

in the SYSTEMIC CIRCULATION

Question 23

The remaining 1/3 exists as pool of platelets in the spleen that free exchange with the general circulation

True or False

Answer 23

TRUE

Question 24

A normal person has an average of how many platelets in the systemic circulation?

Answer 24

250 × 10^9/L

150 ×10^9/L to 450 × 10^9/L

Question 25

The lifespan of a mature platelet is…

Answer 25

9.0 days ± 1 day.

Question 26

Platelet turnover or effective thrombopoiesis averages…

Answer 26

35 ×
10^9/L ± 4.3 × 10^9/L/day

Question 27

What happens to platelets at the end of their lifespan?

Answer 27

platelets are phagocytized by the
liver and spleen and other tissues of the mononuclear phagocytic
system