CHAPTER 4: HEMATOPOIESIS

Question 1

The process of formation and development of blood cells is termed:

Answer 1

Hematopoiesis

Question 2

During the 2nd trimester of fetal development, the primary site of blood cell production is the

Answer 2

Liver

Question 3

What organ is responsible for the maturation of T lymphocytes and regulaiton of their expression of CD4 and CD8?

Answer 3

Thymus

Question 4

The best source of active bone marrow from a 20 year old would be

Answer 4

Iliac crest

Question 5

Physiologic programmed cell death is termed

Answer 5

Apoptosis

Question 6

Which organ is the site of sequestration of platelets?

Answer 6

Spleen

Question 7

What morphologic change occurs during normal blood cell maturation?

Answer 7

Condensation of nuclear chromatin

Question 8

What morphologic change occurs during normal blood cell maturation?

Answer 8

Condensation of nuclear chromatin

Question 9

What cell is a product of the common lymphoid progenitor?

Answer 9

T lymphocyte

Question 10

What growth factor is produced in the kidneys and is used to treat anemia associated with kidney disease?

Answer 10

EPO

Question 11

What cytokine is required very early in the differentiation of a hematopoietic stem cell?

Answer 11

FLT3 Ligand

Question 12

When a patient has severe anemia and the bone marrow is unable to effectively produce red blood cells to meet the increased demand, one of the body’s response is:

Answer 12

Extramedullary hematopoiesis in the liver and spleen

Question 13

Hematopoietic stem cells produce all lineages of blood cells in sufficient quantities over the lifetime of an individual because they what?

Answer 13

Have the ability of self-renewal by asymmetric division