Leprosy Flashcards

1
Q

_____ in Norway discovered the causative agent of leprosy, ______.

A

G.H.A. Hansen

Mycobacterium leprae

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2
Q

This was the first bacterium to be identified as causing disease in humans.

A

Mycobacterium leprae

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3
Q

LEPROSY is A disease also tagged “_______ DISEASE”.

A

HANSEN’S

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4
Q

Leprosy, a (acute or chronic?) , neurological human disease, results from infection with the obligate intracellular pathogen,________ , a close relative of the ________.

A

Chronic

Mycobacterium leprae

tubercle bacillus

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5
Q

_________ has the longest doubling time of all known bacteria

A

M. leprae

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6
Q

M. leprae has never been cultured in the laboratory.
T/F

A

T

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7
Q

________ are the most common host of this leprosy pathogen.

A

Armadillos

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8
Q

Leprosy seems to have originated in __________ and spread with successive human migrations.

A

Eastern Africa or the Near East

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9
Q

In Europe, leprosy first appeared in the records of ancient Greece after ______________________ and then in Rome in 62 B.C. coinciding with the _____________ from Asia Minor.

A

the army of Alexander the Great came back from India

return of Pompeii’s troops

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10
Q

LEPROSY from an epidemiological point of view is characterized by its (high or low?) infectivity and (high or low?) pathogenicity

A

High
Low

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11
Q

about 95% of the population – are naturally immune.

T/F

A

T

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12
Q

Leprosy has a short incubation period

T/F

A

F
Prolonged

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13
Q

Leprosy has low tendency for spontaneous healing
T/F

A

F
High

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14
Q

In addition, men are twice as likely to contract leprosy as women

T/F

A

T

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15
Q

On average, the leprosy disease incubation period is _____ but symptoms may occur within _____. It can also take as long as ______ or even more

A

5 years

1 year

20 years

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16
Q

MDT treatment (__________)

A

Multi-drug Therapy

17
Q

However, a small amount of progress was made in the early 20th century, through the work of Alice Augusta Ball, who developed an injectable solution from ________ that improved the conditions of patients with Hansen’s disease.

The injections became the most reliable way to help keep the disease under control until new drugs became available in the 1940s.

The modern breakthroughs we have today first occurred in the 1940s with the development of the medicine _____—an antibiotic.

A

chaulmoogra oil

dapsone

18
Q

In 1981, WHO recommended MDT. The currently recommended MDT regimen consists of three medicines: ______,_____,_______ .

This treatment lasts ______ for pauci-bacillary and ______ for multi-bacillary cases.

A

dapsone, rifampicin and clofazimine

six months

12 months

19
Q

When did Hansen identify the M.leprae

A

1873