Leprosy Flashcards
_____ in Norway discovered the causative agent of leprosy, ______.
G.H.A. Hansen
Mycobacterium leprae
This was the first bacterium to be identified as causing disease in humans.
Mycobacterium leprae
LEPROSY is A disease also tagged “_______ DISEASE”.
HANSEN’S
Leprosy, a (acute or chronic?) , neurological human disease, results from infection with the obligate intracellular pathogen,________ , a close relative of the ________.
Chronic
Mycobacterium leprae
tubercle bacillus
_________ has the longest doubling time of all known bacteria
M. leprae
M. leprae has never been cultured in the laboratory.
T/F
T
________ are the most common host of this leprosy pathogen.
Armadillos
Leprosy seems to have originated in __________ and spread with successive human migrations.
Eastern Africa or the Near East
In Europe, leprosy first appeared in the records of ancient Greece after ______________________ and then in Rome in 62 B.C. coinciding with the _____________ from Asia Minor.
the army of Alexander the Great came back from India
return of Pompeii’s troops
LEPROSY from an epidemiological point of view is characterized by its (high or low?) infectivity and (high or low?) pathogenicity
High
Low
about 95% of the population – are naturally immune.
T/F
T
Leprosy has a short incubation period
T/F
F
Prolonged
Leprosy has low tendency for spontaneous healing
T/F
F
High
In addition, men are twice as likely to contract leprosy as women
T/F
T
On average, the leprosy disease incubation period is _____ but symptoms may occur within _____. It can also take as long as ______ or even more
5 years
1 year
20 years
MDT treatment (__________)
Multi-drug Therapy
However, a small amount of progress was made in the early 20th century, through the work of Alice Augusta Ball, who developed an injectable solution from ________ that improved the conditions of patients with Hansen’s disease.
The injections became the most reliable way to help keep the disease under control until new drugs became available in the 1940s.
The modern breakthroughs we have today first occurred in the 1940s with the development of the medicine _____—an antibiotic.
chaulmoogra oil
dapsone
In 1981, WHO recommended MDT. The currently recommended MDT regimen consists of three medicines: ______,_____,_______ .
This treatment lasts ______ for pauci-bacillary and ______ for multi-bacillary cases.
dapsone, rifampicin and clofazimine
six months
12 months
When did Hansen identify the M.leprae
1873
