Lecture7: Metabolic Pathways In RBCs

Question 1

What is the first step of the HMS pathway?

Answer 1

Conversion of G6P to R5P + 2 NADPH

Question 2

What initiates the HMS pathway?

Answer 2

G6PD (glucose 6-phosphate dehydrogenase)

Question 3

The enzyme G6PD is inhibited by which mechanism?

Answer 3

Feedback inhibition

Question 4

What inhibits G6PD?

Answer 4

NADPH

Question 5

What happens when insulin concentration increases?

Answer 5

The G6PD gene expression is increased

Question 6

What are the 2 products of HMS pathway?

Answer 6

R-5-P and NADPH

Question 7

What happens to the produced R-5-P?

Answer 7

They are converted to F-6-P and glyceraldehyde 3-phosphate

Question 8

How does the coenzyme NADPH differ from NADH?

Answer 8

a phosphate group.

Question 9

What is the first function of NADPH?

Answer 9

reductive biosynthesis EG. fatty acid production in liver

Question 10

What is the second function of NADPH?

Answer 10

hydrogen peroxide reduction

Question 11

What is the role of NADPH in white blood cells?

Answer 11

NADPH oxidase present in leukocyte cell membrane

Question 12

What does NAPDPH oxidase enzyme do?

Answer 12

Reduces O2 to superoxide anion

Question 13

What is the role of NADPH in nitric oxide synthesis?

Answer 13

substrate to its production

Question 14

What is the role of NADPH in cytochrome p450 system?

Answer 14

Provides the means of reduction

Question 15

What is G6PD deficiency called?

Answer 15

Favism

Question 16

What is Favisim characterized by?

Answer 16

Hemolytic anemia

Question 17

What is the clinical manifestation of Favism?

Answer 17

Neonatal jaundice 1-4 days after birth

Question 18

What is the benefit of Favsim? If any .

Answer 18

resistance to malaria