Lecture2: Structure Of RBC’s And Erythropoiesis Flashcards
What is the function of erythrocytes?
Transport of oxygen and CO2
What does erythrocytes contain?
hemoglobin and some enzymes
What is the average life span of erythrocytes?
120 days
What do erythrocytes display on their surface when they reach the 120 day/age?
Olgiosaccharhides
What is the shape of RBCs’
Biconcave disk-like
Where do RBCs’ develop?
In the Bone marrow
Where is the haemoglobin concentrated?
At the periphery
What are the 2 most abundant transmembrane proteins in Erythrocytes?
Glycophorin A, and Rh factor
What does the ion channel Adenosine Triphosphatase transport?
Cl and HCO3(bicarbonate)
What peripheral proteins are the cytoskeletons attached to?
Ankyrin
What is caused by abnormal spectrin?
Hereditary spherocytosis
What do spheroyctes (cytskeletal defect RBC’s) cause?
Anemia
How is the blood group of a person determined?
Via the carbohydrate chains on the surface of the plasmalemma
Where does hemopoesis occur?
In the bone marrow
How are mature blood cells formed?
Division and differentiation of stem cells
