Lecture5 Flashcards
Ependymal Layer
type of epithelia, forms the lining of all the ventricles, no ependymal brain barrier (anything into CSF can have effect on brain)
Marginal Layer
cell birth (neurons)
Embryonic Day 27
neural tube closed, ependymal layer, marginal layer, mantle layer, division in gray and white matters
Neural Crest
will develop into dorsal root ganglia (just making sure you didn’t forget this from earlier)
Embryonic Day 60
neural tube pinched off and created diamond shape to segregate neurons into place (anterior/basal plate, posterior/alar plate)
Basal Plate
anterior, motor neurons
Alar Plate
posterior, sensory neurons
Sulcus Limitans
groove that separates motor and sensory neurons
General Somatic Efferent
fibers that go away from the nervous system, motor
General Somatic Afferent
fibers that go to nervous system, sensory
Embryonic Day 100
two additional functional components added, general VISCERAL efferent and afferent
Four Functional Components of All Spinal Nerves
GSA, GVA, GVE, GSE
When is nervous system in adult configuration?
end of first trimester
End of Second Trimester Day 200
from dorsal root ganglion pseudounipolar cells have grown into dorsal horn and will synapse on GSA, GVE and GSE will grow out axons and join peripheral process with dorsal root and create spinal nerves, dorsal root ganglia from neural crest, all spinal nerves created
Bror Rexed’s Lamina System
lamina 1-6 are sensory, lamina 7-10 are motor, further segregation according to location of muscles they innervate (midline = proximal = axial, lateral = distal = appendicular)
According to Rexed’s Lamina System, motor columns closest to sensory regions innervate which muscles?
flexors
According to Rexed’s Lamina System, motor columns closest to anterior of the gray matter innervate which muscles?
extensors
Neuronal Clusters
clusters innervate a specific muscle, columns, if damaged the higher the lesion the less function will result, recruit small motor neurons first then larger
White Matter Areas of the Spinal Cord
axons of neurons ascending or descending, different physiological types of fibers based on diameter of fiber and conduction velocity of fibers
Type 1, 2, alpha-beta White Matter Fibers
large diameter and fast conducting fibers, all discriminative sensation (proprioception, 2-point differentiation), enter in from medial portion of dorsal side of spinal cord and synapse on GSA neurons
Type C and Delta White Matter Fibers
small diameter, crude sensation, lateral division of the dorsal horn, synapse on more superficial laminas of the cord (surgeons will cut to alleviate pain)
Fasciculus Gracilis and Fasciculus Cuneatus
somatotropic organization (more medial will be sacral, lateral is lumbar, etc.), dorsal columns get bigger at higher levels