Lecture5 Flashcards

1
Q

Compare the former sensory hierarchical Homogeneous Serial model to the current hierarchical Segregated Parallel model

A

Former - input travels from receptors to thalamus to primary sensory cortex to secondary sensory cortex to association cortex; Current - works as a feedback mechanism where there’s lots of interconnections among the senses at each level of processing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the role of the Pinnae?; What happens when a sound source changes its location relative to the head?

A

They collect sound waves & direct them to the auditory channel; also help to localise sounds - the folds selectively reflect sounds of various frequencies around the ear & into the auditory canal; Frequency profile of reflections changes offering a cue to location of the source

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does the auditory canal do?

A

Offers protection to the middle & inner ear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The vibrations of the tympanic membrane concentrate on what?; How much do the vibrations increase?; What does the lever action of the ossicles do?; Combined, this accounts for a 22 fold increase in what?

A

A very small area on the oval window; 17 fold; Amplifies the vibrations by approx. 1.3 times; The strength of vibrations hitting the tympanic membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How are vibrations converted into neural impulses?; Upward deflection causes…; Downward deflection causes…

A

Hair cells (stereo cilia) lie between the tectorial & basilar membrane (which are joined at one end) & the shear force of both membranes activate the hair cells causing a neural impulse; Hair cells to bend to the right; Hair cells to bend to the left

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

At auditory threshold what is the measurement of hair cell displacement?

A

100 picometres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What 3 processes does the auditory system use to code for different frequencies?

A

Frequency theory - firing rate codes directly for those frequencies; Volley theory - none can code on their own for a particular frequency but can cooperate, if each a little out of phase the sum of them can total 400hz; Place theory - depends on specific properties of basilar membrane, high frequencies travel only a short distance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the base of the basilar membrane tuned for?; What is the apex of the cochlear tuned for?

A

High frequencies (point of maximum deflection); Low frequencies (travels further)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where is the auditory receiving area?; In order, what other auditory pathways are involved?

A

Temporal lobe; Cochlea, Auditory Nerve, Cochlea Nuclei, Superior Olivary Nuclei, Lateral Lemniscus, Inferior Colliculus (tectum), Medial Geniculate Nucleus (thalamus), Primary Auditory Cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are Interaural Time Differences?; If sound source comes directly in the right ear how long before it reaches the left ear?

A

Measurable & detectable time for sound to travel across the width of the head; A few milliseconds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Explain Interaural Intensity Differences

A

Higher frequencies tend to bounce off objects (e.g. if a sound goes directly into right ear the intensity is less in left ear because of acoustic shadow), but lower frequencies can bend around obstacles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Explain the process of sound localisation by interaural differences with sound entering the left ear

A

Sound reaches the left ear first, action potential begins travelling toward Medial Superior Olive (longer path to last neuron), sound reaches right ear, action potential from right ear travels toward MSO (shorter path to first neuron), action potentials converge on an MSO neuron that responds most strongly if their arrival is coincident

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

If a sound source from straight ahead equally stimulates both Medial Nuclei of the Trapezoidal Body (MNTB) & completely shuts down the Lateral Superior Olive (LSO) on both sides, what occurs if sound source comes from the left?

A

Stronger stimulus to left ear excites left LSO, this also inhibits contralateral (right) side LSO via MNTB interneuron, excitation from left is greater than inhibition from right resulting in net excitation to higher centres, inhibition from left is greater than excitation from right resulting in net inhibition on right & no signal to higher centres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the 2 principles of organisation in the auditory cortex?

A

Columnar oragnisation (i.e. frequency columns) & Tonotopic organisation of the cochlea is preserved all the way up the auditory pathway (this results from projections from specific locations along basilar membrane)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where does the core area lie?; What is it called?; Where does the belt area lie?; What is this called?

A

Inferior to the lateral fissure in the temporal lobe; Primary auditory cortex; inferior to Primary auditory cortex; Secondary auditory cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does Conduction Deafness result from?; Give an example of this; What part of the system does this not involve?

A

Damage to the tympanic membrane & ossicles; Ossicles can become fused & no longer transmit sound vibrations from the outer ear to cochlea (mechanical process); Nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the main feature of Sensorineural Deafness?; Deafness is…; What is this caused by?

A

Auditory nerve fibres are not stimulated properly; Permanent; Infection, trauma, exposure to toxic substances, loud sounds (e.g. noise pollution, headsets)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What properties does the antibiotic, Streptomycin have?; What did tuberculosis patients treated with this result in?

A

Ototoxic properties (ear damaging); Cochlea damage - in some cases all hair cells in the cochlea were destroyed, leading to total deafness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is Central Deafness caused by?; What does this result in?

A

Brain lesions in the temporal lobes of the cortex (e.g. stroke); Loss of specific faculties, such as language processing (left lobe) or discrimination of non-language sounds (right lobe)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What does the Meaningful Sounds Identification test measure?; How do patients with left temporal damage perform on this test?; Patients with right temporal damage?

A

The ability to match the correct semantic meaning to a sound; Poorly; Equally to normal controls

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What does the Meaningless Sounds Discrimination test measure?; How do patients with left temporal damage perform on this test?; Patients with right temporal damage?

A

The perceptual ability to discriminate between physically distinct sound patterns; Equally to normal controls; Poorly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is the vestibular system critically important for?

A

In maintaining eye movements & balance

23
Q

Explain the Roll rotation; Pitch rotation; Yaw rotation; How are these rotations translated?

A

Around x-axis (left to right); Around y-axis (front to back); Around z-axis (horizontal); Into flow in semi-circular canals

24
Q

Vestibular neurons tend to fire even without stimulation. What does this allow them to do?; Spikes increase rapidly with onset of…

A

Signal 2 directions of acceleration - increasing firing for one direction & decreasing firing for the other; Acceleration

25
Q

At a constant velocity what does the cupula (the hinged flap in vestibular) do?; With deceleration, what does the inertia of the semi-circular canal do?

A

Returns to original position & slows firing to baseline; Deflect the cupula in the opposite direction & inhibit firing, before returning back to baseline

26
Q

Name the 2 otoliths; Which one gives a sense of which way is up?

A

Utricle & Saccule; Saccule

27
Q

What do the otoliths respond to?; Forces acting on the head result in displacement of what?; Due to translational movements, how do the hair cells respond?; What can tilting the head forward or backward produce?

A

Linear acceleration & gravity; The Otolithic Membrane of the Utricula Macula; Some will be maximally excited & another set will be maximally inhibited; Displacements similar to certain accelerations (creates an illusion)

28
Q

How does a vestibular nerve from an otolith organ respond when the chin is tilted up?; How does it respond when the chin is tilted down?

A

Increased activity (reaching almost 120 spikes p/sec); Sustained reduced activity (down to around 20 spikes p/sec)

29
Q

What are Optokinetic Nystagmus?

A

Rhythmic eye movements that compensate for movements of the visual scene relative to the viewer; they’re driven by motion across the retina (e.g. looking out the window of a moving train)

30
Q

What are Vestibulo-ocular reflexes driven by?; The slow phase is to…; The fast phase is to…

A

Stimulation of the semi-circular canals & utricles; Keep the image stable on the retina as much as possible; Snap the eye back into position to be ready to track again (image smeared on retina & vision is impaired)

31
Q

Explain the connections underlying the vestibulo-ocular reflex?

A

When the head turns to the left our eyes reflexively compensate & go to the right; Medial Rectus from left eye & Lateral Rectus from right eye send excitatory signals to midbrain & pons, respectively, before descending to rostral medulla

32
Q

What condition occurs with the bilateral loss of vestibulo-ocular reflex?; What are the symptoms?

A

Oscillopsia (Bouncing vision); Sensation that the world is moving whenever the head moves; information about head movements signalled by the vestibular organs is unavailable; compensatory eye movements are not made

33
Q

What do the Vestibulo-spinal reflex (VSR) & the Vestibulo-cervical reflex (VCR) help us do?

A

Regain balance if we mis-step; provide a quick compensation

34
Q

Somatosensory system is comprised of what 3 systems?

A

Exteroceptive: senses external stimuli applied to the surface of the skin; Proprioceptive: senses position of the limbs via joint angles, body posture, vestibular senses; Interoceptive: senses general conditions within the body such as temperature & blood pressure

35
Q

Name the 4 Cutaneous Receptors; In every case, what do the receptors change their electrical properties in response to?

A

Free nerve endings, Pacinian corpuscles, Merkels’s discs & Ruffini endings; Mechanical deformations of the skin (resulting in an action potential)

36
Q

What are Free Nerve Endings sensitive to?

A

Temperature & pain (they have no specialised structure)

37
Q

What do Pacinian Corpuscles respond to?

A

They respond rapidly to transient pressure but adapt to it quickly

38
Q

What do Ruffini Endings respond to?; How do they adapt?

A

Gradual stimulation of prolonged pressure or stretching of the skin; Slowly

39
Q

When afferent nerve fibres over a specific area of the body converge on specific dorsal roots in the spinal cord, what is this area called?; If there’s damage or loss of one?

A

Each area is called a Dermatome; It doesn’t result in a large deficit in sensation of the Dermatome as there’s considerable overlap

40
Q

Somatosensory information ascends from each side of the body to the cortex via which two pathways?

A

Dorsal Column Medial-Lemniscus - a single tract which carries information about touch & proprioception; Anterolateral System - carries information about pain & temperature (more diffuse)

41
Q

In the Dorsal Column Medial-Lemniscus, sensory neurons enter the spinal cord via the dorsal root & ascend….; Where do these fibres synapse & decussate?; They continue to ascend on the other side via the….; To the…

A

Ipsilaterally in dorsal columns; In the Dorsal column nuclei; Medial lemniscus; Ventral posterior nucleus of the thalamus

42
Q

Which facial nerves connect to the ventral posterior nuclei via the Medial lemniscus?

A

Trigeminal nerves

43
Q

The Anterolateral System is composed of 3 separate tracts. What are they & where do they project?

A

Spinothalamic tract - to the ventral posterior nucleus; Spinoreticular tract - to the reticular formation, then parafasicular nuclei, then intralaminar nuclei in the thalamus; Spinotectal tract - to the tectum

44
Q

In the Anterolateral System, when do the sensory neurons synapse?; Then what happens?

A

As soon as they enter the spinal cord; They decussate immediately & proceed up the contralateral side

45
Q

What is a probable explanation for the fact that damage to Primary Somatosensory Cortex (S1) is not marked by major deficits in sensation?

A

Due to the numerous parallel pathways in the two systems

46
Q

Why is pain an adaptive function?; The cortical representation of pain is what?; If S1 or S2 are removed what will happen?; Full removal of an entire hemisphere….

A

It stops us from doing damage to ourselves & encourages us to seek treatment; Diffuse - no single structure is responsible; Sensitivity to pain will not reduce; Has little effect on pain threshold

47
Q

What has the Anterior Cingulate Gyrus been implicated in mediating?; PET studies showed an increase in activity when participants did what?; What is this structure more likely involved in?; How do results from a prefrontal lobotomy support this?

A

Perception of pain; Touched very hot or cold objects; Emotional response to pain; There is a reduced emotional response to pain but no change in pain threshold

48
Q

Explain how the Periaqueductal Grey (PAG) works as a descending internal pain controlling mechanism

A

Has analgesic effects; electric stimulation reduces pain; has receptors for opiate based pain drugs; activity is modulated by endorphins

49
Q

Where are receptors for the Olfactory System?; Chemicals are inhaled to the…; Why, according to the olfactory process, could smell be a powerful memory cue?

A

In the nasal cavities; Olfactory Bulb; There’s a direct connection from olfactory receptors right through to the medial dorsal nucleus in the thalamus (associated with memory generation)

50
Q

In the Gustatory system, what are the textured bumps containing taste receptors on taste buds?; What is their purpose?; Which Papillae lie at the back of the tongue?; Sides of the tongue?; Tip of the tongue?

A

Papillae; They maximise the surface area to facilitate chemical reactions; Circumvallate; Foliate; Fungiform Papillae

51
Q

What are the five main tastes?

A

Salty, Sweet, Sour, Bitter & Umami

52
Q

The Facial, Vagus & Glossopharyngeal nerves are what?; Where does the first synapse occur in the gustatory system?

A

Taste receptors; Solitary Nucleus

53
Q

What is Anosomia?; What is a common cause?

A

The inability to smell; A blow to the head such that the brain shifts in the skull & the axons from olfactory receptors are sheared off when they enter the skull

54
Q

What is Aguesia?; Why is this very rare?

A

The inability to taste; Probably due to the diffuse afferent tracts from the taste receptors (facial, vagus & glossopharyngeal nerves)