Lecture1 Flashcards
Medial:
Towards midline
Lateral:
Away from midline
Dorsal / Superior:
Towards back / Top of head
Ventral / Inferior:
Towards chest / Bottom of head
Anterior:
Towards nose end
Posterior:
Towards tail end
Frontal/Coronal plane:
Sliced across left to right
Sagittal plane:
Sliced vertically through the middle
Horizontal plane:
Sliced horizontally through the middle
Cross Section:
Sliced at right angle across tract of nerves
The vertebrate nervous system is composed of what two divisions?
Central Nervous System (CNS) & Peripheral Nervous System (PNS)
Where is the CNS located?
Within the Brain & Spinal cord
Where is the PNS located?; What does it do?
Outside the skull & spine; Transmits information to & from the CNS
What are Nuclei?
Clusters of cell bodies in the CNS
What are Ganglia?
Clusters of cell bodies in the PNS
Name the four regions that divide the spine:
Cervical; Thoracic; Lumbar & Sacral
The two major divisions of the PNS are:
Somatic & Autonomic nervous systems
Which division of the PNS interacts with the external environment? Afferent nerves carry…; Efferent nerves carry…
Somatic; Sensory signals from external receptors (skin, etc) to CNS; Motor signals from CNS to skeletal muscles
Which division of the PNS regulates the body’s internal environment? Afferent nerves carry…; Efferent nerves carry…
Autonomic; Sensory signals from internal organs to CNS; Motor signals from CNS to internal organs
Which division of the PNS includes voluntary/conscious control of signals?
Somatic nervous system
Which efferent nerves project from the CNS in the lumbar & thoracic regions of the spinal cord?; What do they do?
Sympathetic nerves; Stimulate & organise energy in threatening situations (fight or flight response)
Which efferent nerves project from the brain & sacral region? What do they do?
Parasympathetic nerves; Conserve energy during periods of quiescence
Which system contains the Sympathetic & Parasympathetic nerves?
Autonomic nervous system
What are the longest cranial nerves called?; What do they contain?
Vagus nerves; Motor & sensory fibres traveling to & from the gut
What are the Dura Mater, Arachnoid Meninx & Pia Mater?
Meninges - protective membranes covering the brain & spinal cord
Dura Mater:
“Tough mother”; thick, outermost meninge; anchor to the brain
Arachnoid Meninx:
Spider-like delicate lattice of tissue; provides a scaffold for blood vessels
Pia Mater:
“Pious mother”; thin; delicate; innermost meninx; fixed directly to cortex
What lies beneath the arachnoid meninx & contains blood vessels & cerebrospinal fluid?
Subarachnoid space
What fills the subarachnoid space, central canal of spinal cord & cerebral ventricles of brain?; What does it do?
Cerebrospinal Fluid (CSF); Protects & cushions the brain; drains through jugular veins & cerebral aqueduct
What is the Choroid Plexus? What does it do?
Networks of capillaries that protrude into ventricles from Pia Mater; Continuously produces & replaces CSF (5 x p/day)
Where does the Cerebral Aqueduct lie?
It connects the 3rd & 4th ventricles
What condition occurs if CSF is blocked by a tumour, leading to expansion of ventricle walls & entire brain?
Hydrocephalus (water head)
What protects the brain physically?
Skull, Menenges (dura mater, arachnoid meninx, pia mater meninx) & CSF
What protects the brain from chemical invasion?; How?
The Blood-Brain Barrier; Tightly packed cells along blood vessel walls (in CNS) prevent entry of many large molecules
Quadriplegia is caused by paralysis of which nerves?
Cervical nerves (C1-C8)
Which nerves can be affected in paraplegia?
Thoracic (T1-T12), Lumbar (L1-L5) & Coccygeal nerve
Forebrain:
Telencephalon (cerebral hemispheres) & Diencephalon
Midbrain:
Mesencephalon
Anterior part of hindbrain:
Mentencephalon (pons & cerebellum)
Hindbrain:
Myelencephalon (medulla)
31 pairs of spinal nerves are attached to the:
Spinal cord
What is the inner core of grey matter in the spinal cord composed of?
Cell bodies & unmyelinated interneurons
What is the white matter surrounding the grey matter mostly composed of?
Myelinated axons
What sort of neurons are dorsal root axons? Where are their synaptic terminals?
Sensory (afferent) unipolar neurons; In dorsal horns of spinal grey matter
What sort of neurons are of the ventral root? Where do their cell bodies lie?
Motor (efferent) multipolar neurons; in the ventral horns
What lies in the middle of the grey matter in the spinal cord?
Central canal
Myelencephalon (medulla) lies in the: It is composed of…; It includes the…; Which regulates…
Brain stem; Neural tracts projecting signals to spinal cord; Reticular formation; Sleep cycles, arousal, attention, movement & reflexes
Metencephalon houses part of the…; 2 major divisions include the…
Reticular formation; Pons & cerebellum
The cerebellum governs…; Damage can result in…
Sensory & motor control; Parkinson’s & cognitive deficits
What are the 2 divisions of the mesencephalon?
Tectum (dorsal surface of midbrain) & Tegmentum (ventral)
Where are the pairs of Superior & Inferior Colliculus (little hills) found? What’s the difference between the two?
Tectum; Superior Colliculi are in the anterior part & have a visual function; Inferior Colliculi are in the posterior part & have an auditory function
What 3 structures does the Tegmentum contain?
Periaqueductal Gray, Substantia Nigra & Red Nucleus
Which structure in the tegmentum regulates pain & mediates effects of opiates?
Periaqueductal Gray
Where is the Periaquaductal Gray situated?
Around the Cerebral Aqueduct
What is the Substantia Nigra responsible for?; If it’s diminished?
Production of dopamine; Can lead to Parkinson’s
Which 2 structures compose the Diencephalon?; What are their roles?
Thalamus: receives, processes & transmits sensory signals; Hypothalamus: controls pituitary gland; regulates behaviours (fight/flight/feed/fuck)
The thalamus is composed of 3 major nuclei. They include:
Lateral Geniculate, Medial Geniculate & Ventro Posterior Nucleus
Lateral Geniculate Nucleus:
Primary relay centre for visual information; 1st synapse after optic nerve leaves eye
Medial Geniculate Nucleus:
Responsible for Auditory relay
Ventro Posterior Nucleus:
Responsible for Sensorimotor relay
Anterior part of frontal lobe governs…; Posterior part is the…
Executive control planning; Motor area
What does the Central Fissure lie between?
Precentral Gyrus (frontal lobe) & Postcentral Gyrus (parietal lobe)
What area is the Anterior part of the parietal lobe?
Somatosensory area
What divides frontal & temporal lobes?
Lateral Fissure
What lies inferior/ventral to the Lateral Fissure?
Superior Temporal Gyrus
What part of the temporal lobe is the area of Superior Temporal Gyrus responsible for?
Hearing & language
Where is visual information processed?; Where is it located?
Occipital lobe; Posterior part of brain
What 2 main cell types is the Neo-Cortex composed of?
Stellate Cells (interneurons) & Pyramidal Cells (large multipolar neurons)
How do each of the 6 layers of tissue in the Neo-Cortex differ?
In relative concentration of stellate & pyramidal cells & relative size & concentration of cell bodies
What is the basis of columnar organisation in the Neo-Cortex?
Vertical flow of information via long axons
Which layer of the neo-cortex can the visual cortex be found?; Which layer can the motor cortex be found?
4th; 5th
Parkinson’s disease is associated with the degeneration of the pathway between which 2 areas of the brain?
Striatum & Substantia Nigra in the mid-brain
The Cerebral Cortex includes the:
Neocortex & Hippocampus
What are the Major fissures?
Central, Lateral & Longitudinal fissures
What are the Major gyri?
Precentral, Postcentral, Superior Temporal & Cingulate Gyrus
The 4 lobes include:
Frontal, Temporal, Parietal, Occipital lobes
What makes up the Limbic System?
Amygdala, Hippocampus, Fornix, Cingulate Cortex, Septum & Mammillary bodies
Basal Ganglia consists of:
Amygdala, Striatum (Caudate, Putamen) & Globus Pallidus
Cerebral Commissures include the:
Corpus Callosum
Cerebral Cortex, Fissures, Gyri, 4 lobes, Limbic system, Basal Ganglia & Cerebral Commissures are all part of the:
Telencephalon in the forebrain
Thalamus consists of:
Massa Intermedia, Lateral geniculate nuclei, Medial geniculate nuclei & Ventral posterior nuclei
Hypothalamus consists of:
Mammillary bodies
Thalamus, Hypothalamus, Optic Chiasm & Pituitary gland are all found in the:
Diencephalon in the forebrain
Reticular formation, Pons & Cerebellum make up the:
Metencephalon in the hindbrain
As well as the Metencephalon, part of the Reticular formation is found in the:
Myelencephalon (medulla) in the hindbrain
Tectum includes the:
Superior & Inferior Colliculi
Tegmentum consists of:
Reticular formation, Cerebral aqueduct, Periaqueductal gray, Substantia nigra & Red nucleus
Both the tectum & tegmentum are found in the:
Mesencephalon in the mid-brain
What is processed in the Amygdala?
Emotion
What does the Hippocampus process?
New memories