Lecture Slides - Dose Response Curve & Interactions (pg. 4-7)

Question 1

“amount required to produce a given effect”

Answer 1

potency

Question 2

___ ____: efficacy compared to drug with “maximum” efficacy

Answer 2

intrinsic activity

Question 3

two drugs having similar efficacy would also have similar ___ ___ ___

Answer 3

rates of change

Question 4

Dose response curves:

• relative?
• absolute?

Answer 4

• potency and intrinsic activity

- efficacy and effectiveness

Question 5

____ = max response achievable (for a specific dose)

Answer 5

efficacy

Question 6

____ : the ability to produce a given effect

Answer 6

effectiveness

Question 7

Drug interactions change ____ and ____ curves

Answer 7

potency and effectiveness

Question 8

3 areas in which one drug can effect the efficacy of another?

Answer 8

• absorption
• transport
• metabolism

Question 9

____ effects whether or not your body holds on to an acid or base depending on pH

Answer 9

motility

Question 10

what three ways can antagonism occur?

Answer 10

a drug can block another drug, your body can block a drug, a chemical can block a drug

Question 11

What does toxicity do?

Answer 11

it blocks other drugs from doing what they are supposed to be doing - this is one molecule keeping another molecule from doing what it is supposed to be doing

Question 12

Enzymatic ____ - additive: one blocks, the other lingers

Answer 12

inhibition

Question 13

Enzymatic ____ - antagonism: one facilitates, the other breaks down

Answer 13

induction

Question 14

______ _____: when a drug affects another drug in some way - they compete and there is a diminished/reduced effect in the presence of another drug

Answer 14

Pharmacological antagonism

Question 15

competitive vs. non-competitive drug interactions?

Answer 15

Competitive: bind to receptor sites - changes receptor complex and depending on how it changes site, different things will happen
Non-Competitive: bind to receptor or allosteric site - max result is reduced

Question 16

_____ _____ : a substance that produces an effect that counteracts the drug - this occurs without binding to the receptor site (doesn’t affect drug itself)

Answer 16

physiological antagonism

Question 17

When a drugs effects are combined, what are the two additive effects that are seen?

Answer 17

synergism and potentiation

Question 18

____: a combined effect greater than the sum

Answer 18

synergism; 2+2=10

Question 19

____: a drug with little/no effect becomes more effective in presence of another drug - why does this happen?

Answer 19

potentiation; metabolites interact and decomposition can be delayed