Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematology 2 > Lecture - Module 5 > Flashcards

Lecture - Module 5 Flashcards

1
Q

a disease, usually of leukocytes, in the blood and bone marrow

A

LEUKEMIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Symptoms of short duration
Many immature cell forms in the bone marrow and/or peripheral blood
Elevated total leukocyte count

A

Acute Leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Symptoms of long duration
Mostly mature cell forms in the bone marrow and/or peripheral blood
Total leukocyte counts that range from extremely elevated to lower than normal.

A

Chronic Leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

is a general term for malignancy that starts in the lymph system, mainly in the lymph nodes.

A

LYMPHOMAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Proliferation of malignant lymphocytes which have a basophilic vacuolated cytoplasm with starry sky pattern due to numerous tangible body macrophage that are arrested at certain stages of maturation

A

HODGKIN LYMPHOMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

presence of Reed Sternberg cell (large binucleated or multinucleated cell resembles owl’s eye appearance with each nucleus bearing a very large nucleolus.

A

HODGKIN LYMPHOMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Diffuse large B-cell lymphoma

A

NON-HODGKIN LYMPHOMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Reed-Sternberg is absent but mixed population of lymphocytes, histiocytes, eosinophils and some plasma cells are present.

A

NON-HODGKIN LYMPHOMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

is a form of cancer of the plasma cells.

A

MYELOMAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

cells overgrows, forming a mass or tumor that is located in the bone marrow.

A

MYELOMAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Malignant cells freely trespass the blood brain barrier

A

Leukemias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Malignant cells are initially confined to the organs containing mononuclear phagocyte cells such as the lymph nodes, spleen, liver, and bone marrow.

A

Lymphomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Plasma cells form a mass or tumor that is located in the bone marrow.

A

Myelomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

________ can spill over into the circulating blood and present a _____ appearing picture on a peripheral blood smear.

A

lymphomas

leukemic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

three broad leukocytes groups according to FAB

A
  1. Myelogenous
  2. Monocytic
  3. Lymphocytic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Classification of WHO is based on

A

morphology with immunophenotyping and genetic studies of peripheral blood, bone marrow, and lymph node samples.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

ACUTE LEUKEMIAS have _______ and total leukocyte count is __________ or normal or decreased leukocyte count

A

anemia

usually elevated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

remains a lethal disorder, which kills the majority of afflicted adults.

A

AML

ANLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

most common leukemia subtype

recognized as a heterogenous clonal disorder

A

ACUTE MYELOID LEUKEMIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

characterized by:
Maturation block and the accumulation of acquired somatic genetic alterations in hematopoietic progenitor cells that alter normal mechanisms of self- renewal, proliferation, and differentiation.

A

ACUTE MYELOID LEUKEMIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Undifferentiated blasts, AML— not otherwise categorized

A

M0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Blasts and promyelocytes predominate without further maturation of myeloid cells
WHO synonym for this condition is acute myeloblastic leukemia without maturation.

A

M1 (myeloid)

23
Q

Myeloid cells demonstrate maturation beyond the blast and promyelocyte stage
WHO synonym for this disease is acute myeloblastic leukemia with maturation.

A

M2 (myeloid)

24
Q

Promyelocytes predominate in the bone marrow

A

M3 (promyelocytic)

25
Q

Both myeloid and monocytic cells are present to the extent of at least 20% of the total leukocytes

A

M4 (myelomonocytic)

26
Q

referred to as Naegeli type monocytic leukemia.

A

M4 (myelomonocytic)

27
Q

WHO synonym is acute myelomonocytic leukemia

A

M4 (myelomonocytic)

28
Q

characterized by large blasts in bone marrow and peripheral blood

A

FAB M5a

29
Q

FAB M5a is common in

A

young adults

30
Q

differentiated type by monoblasts, promonocytes, and monocytes

A

FAB M5b

31
Q

FAB M5b is common in

A

middle age

32
Q

M5 (monocytic) is referred to as

A

SCHILLING’S TYPE

33
Q

M6 (erythroleukemia) referred to as

A

Erythemic Myelosis

Di Guglielmo syndrome

34
Q

Abnormal proliferation of both erythroid and granulocytic precursors; may include abnormal megakaryocytic and monocytic proliferations

A

M6 (erythroleukemia)

35
Q

Large and small megakaryoblasts with a high nuclear cytoplasmic ratio; pale, agranular cytoplasm

A

M7 (megakaryocytic)

36
Q

WHO synonym is acute megakaryoblastic leukemia

A

M7 (megakaryocytic)

37
Q

ACUTE MYELOID LEUKEMIA (WHO CLASSIFICATION)

A

ACUTE MYELOID LEUKEMIA WITH CERTAIN GENETIC ABNORMALITIES
not otherwise specified
ambiguous lineage

38
Q

ALL is the most common cancer in children, representing 23% of cancer diagnoses among children younger than 15 years of age

A

ACUTE LYMPHOBLASTIC LEUKEMIA

39
Q

Small Indistinct Scant Invisible

what fab type

A

L1

40
Q 
Large, heterogeneous
Indented, prominent
Large, abundant
Moderately clefted
What fab type
A

L2

41
Q 
Large 
Regular oval to round
Prominent, basophilic
Prominent, vacuoles
What fab type
A

L3

42
Q

neoplasm of lymphoblasts committed to the B-cell lineage

A

Precursor B lymphoblastic leukemia/lymphoblastic lymphoma (precursor B-cell ALL)

43
Q

neoplasm of lymphoblasts committed to the T-cell lineage.

A

Precursor T lymphoblastic leukemia/lymphoblastic lymphoma (precursor T-cell ALL)

44
Q

One population of cells within the case; small cells predominant; nuclear shape is regular with an occasional cleft; chromatin pattern is homogeneous and nucleoli are rarely visible; cytoplasm is moderately basophilic

A

L1 (homogeneous)

45
Q

Large cells with an irregular nuclear shape; clefts in the nucleus are common; one or more large nucleoli are visible; cytoplasm varies in color

A

L2 (heterogeneous)

46
Q

Cells are large and homogeneous in size; nuclear shape is round or oval; one to three prominent nucleoli; cytoplasm is deeply basophilic with vacuoles often prominent

A

L3 (Burkitt lymphoma type)

47
Q

CLINICAL SIGNS & SYMPTOMS of acute lymphoblastic leukemia

A

Pain in lower extremities
Lymphadenopathy
Hepatomegaly
Leukemic meningitis

48
Q

These signs of acute lymphoblastic leukemia are present in 75% of patients.

A

Lymphadenopathy

hepatomegaly

49
Q

Total leukocyte count in acute lymphoblastic leukemia

A

elevated, 50 to 100 × 109/L

50
Q

< 15% of patients exhibits ________ in acute lymphoblastic leukemia

A

extreme leukocytosis

TL > 100 × 109/L

51
Q

Approx. 25% of patients exhibits __________ in acute lymphoblastic leukemia

A

leukocytopenia

52
Q

In the peripheral blood smear of acute lymphoblastic leukemia, there is a predominant in

A

blast cells

53
Q

in acute lymphoblastic leukemia, peripheral blood smear contains

A

lymphoblasts
lymphocytes
smudge cells

Hematology 2 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions