Lecture final Flashcards
(118 cards)
what test is the most reliable assessment of the effective erythroid activity of the bone marrow?
retic count
what conditions (including parasitc infections) produce a macrocyitic/normochromic picture?
pernicious anemia
liver disease
folate deficiency
B12 deficiency
what conditions produce a microcytic/hypochromic blood picture?
thalassemia iron deficiency sideroblastic anemia Lead poisoning hookworm infection
what are the typical findings in pernicious anemia?
oval macrocytes
shift to the right
BM WBC precursors, giant band and metas
what is the schilling test and what body fluid is used for the test?
indirect measure of intrinsic factor (pernicious anemia)
urine
what are macropolycytes?
large cells with 5-7 lobes in nucleus. larger than hypersegs
what portion of the red blood cell is damaged leading to the formation of burr cells and thorn cells?
membrane
what are the distinguishing characteristics of hereditary ovalocytosis?
ovalocytes
Normal Hgb and normal cental palor
what is the most unusual and significant finding in patients suffering for AIHA?
positive direct coobs test (DAT)
what poikilogyte is associated with ABO HDN?
spherocytes (not normal)
what poikilocyte is associated with extramedullary hematopoiesis?
tear drop cells
what are the lab finding is PCH?
positive DAT
positive Donath Landsteiner
syptoms after exposure to cold
what are the hemoglobin electrophoresis results in sickle cells anemia?
Has Hgb S and F
No Hgb A
hat hemoglobin is insoluble in reducing agents such as sodium dithionite and sodium meatbisulfate?
Hgb S
which beta chain of the Hgb molecule is abnormal in Hgb C disease, sickle cell anemia and thalassemia major?
beta chain
what does the PBS of a patient with sickle cells trait usually look like?
occcasional target cells otherwise normal
what does the PBS of a patient with IDA show?
pale, microcytic/hypochromic cells
what are the serum iron and TIBC results in IDA?
decreased iron increased TIBC
what is the specific cause of thalassemia?
decreased rate of synthesis of either slpha or beta chains. inherited not normal
what is another name for homozygous alpha thalassemia?
barts disease
what is another name for heterozygous alpha thalassemia?
Hgb H disease
what cause relative polycythemia?
stress
dehydration
severe burns
not increased erythropoeiten
what are the typical lab findings in acute leukemia?
anemia
thrombocytopenia
young cells
what has auer rods and a positive peroxidase stain?
AML