Lecture Exam 3 Flashcards
What are the functions of blood:
- Carries respiratory gases, nutrients, hormones and metabolic wastes
- Regulates pH of interstitial fluid
- Restrict fluid loss at injury sites
- Defense against toxins and pathogens
- Helps body regulate temperature
What is plasma?
Straw-colored, sticky fluid portion of blood.
90% water.
What are the components of plasma?
Ions nutrients wastes oxygen hormones vitamins proteins
Types of proteins found in plasma:
Albumin (60%)
Globulin (30%)
Fibrinogen (5%)
Regulatory proteins (
How is plasma different from interstitial fluid?
It contains proteins and different levels of gases.
What is a hematocrit?
The percentage of the blood volume that consists of erythrocytes, averages 45%
(Males: 47%, Females: 42%)
What is hematopoiesis?
Process by which blood cells are formed. 100 billion new blood cells formed each day.
The 2 main stem cells that originate from the blood stem cell:
Lymphoid stem cells
Myeloid stem cells
What are the functions of red blood cells?
Transport oxygen and carbon dioxide
How many red blood cells do we have per mm^3?
4-6 million
How is the structure of RBC related to the function?
Their biconcave shape provides 30% more surface area than spherical cells of the same volume, allowing rapid diffusion of oxygen into and out of erythrocytes.
How long do red cells circulate for?
100-120 days
Which organs remove old blood cells?
Mainly the spleen, also the liver.
The 5 types of white blood cells:
Granulocytes:
- Neutrophils
- Eosinophils
- Basophils
Agranulocytes:
- Lymphocytes
- Monocytes
Neutrophil function:
Destroy bacteria by phagocytosis
Eosinophil function:
Turn off allergic responses and kill parasites
Basophil function:
Release histamine and other mediators of inflammation
Lymphocyte function:
Mount immune response by direct cell attack (T cells) or via antibodies (B cells)
Monocyte function:
Phagocytosis; develop into macrophages in tissues
Where are white blood cells formed?
In the bone marrow
Platelets:
Not cells.
Disc-shaped, plasma membrane- enclosed fragments of cytoplasm that form by breaking off of larger cells called megakaryocytes.
Megakaryocytes are precursor of platelets.
What type of tissue is blood?
A specialized type of connective tissue
Why is the heart considered a double pump?
It has two sides that pump. The right side of the heart pumps blood through the pulmonary circuit. The left side of the heart pumps blood to all the body tissues via the systemic circuit.
The 3 layers of the pericardium:
- Fibrous pericardium (dense C.T.)
- Serous pericardium: parietal layer and viscera layer (both C.T.)
Function of pericardial fluid:
Reduce friction between the beating heart and the outer wall of the pericardial sac
Layers of the heart wall:
- Epicardium
- Myocardium
- Endocardium
The 4 chambers of the heart:
Right atrium
Right ventricle
Left atrium
Left ventricle
Function of right atrium:
Receives blood from systemic circuit via superior vena cava, inferior vena cava, and coronary sinus
Function of right ventricle:
Receives blood from right atrium thru the tricuspid valve. Pumps blood into pulmonary circuit via pulmonary trunk.
Function of left atrium:
Receives oxygen-rich blood from lungs thru pulmonary veins.
Function of left ventricle:
Pumps blood thru systemic circuit via aortic semilunar valve (aortic valve).
Why are atrial walls thin?
The blood is pumped down to the ventricles, which are larger pumping chambers which must propel blood out of the heart so they contain more muscle tissue than the atria do.
Which ventricle has a thicker wall? Why?
The left ventricle has thicker walls then the right, because it needs to pump blood to most of the body, while the right ventricle fills only the lungs
Name the three major veins opening into the right atrium:
- Superior vena cava
- Inferior vena cava
- Coronary sinus
Name the two major arteries leaving the heart from the ventricles:
- Pulmonary trunk
- Aortic valve
Trace blood thru all heart chambers and heart valves:
Blood coming from the body regions superior to the diaphragm (not including heart wall) enters the R atrium via the SVC; blood returning from the body regions inferior to the diaphragm enters the IVC; and blood draining from the heart wall itself is collected by and enters the R atrium thru the coronary sinus. The blood passes from the atrium thru the tricuspid valve to the R ventricle, propelled by gravity and the contraction of the R atrium. Then, the R ventricle contracts, propelling the blood thru the pulmonary semilunar valve into the pulmonary trunk and to the lungs thru the pulmonary circuit for oxygenation. The freshly oxygenated blood returns via the 4 pulmonary veins to the L atrium and passes thru the mitral valve to the L ventricle, propelled by gravity and the contraction of the L atrium. The L ventricle then contracts and propels the blood thru the aortic semilunar valve into the aorta and its branches. After delivering oxygen and nutrients to the body tissues thru the systemic capillaries, the oxygen poor blood returns thru the systemic veins to the R atrium- and the whole cycle repeats continuously.
Structure and location of semilunar valves:
Each has 3 pocket-like cusps shaped roughly like crescent moons. Located at the junction of the ventricles and the great arteries.
How do semilunar valves work to prevent the back flow of blood in the heart?
When the ventricles contract and raise the intraventricular pressure, the semilunar valves are forced open, and their cusps are flattened against the arterial walls as the blood rushes past them. When the ventricles relax, blood that tends to flow back toward the heart fills the cusps of the semilunar valve and forces them shut.
Structure and location of atrioventricular valves:
Located at the junctions of the atria and their respective ventricles are the atrioventricular valves: the R atrioventricular (tricuspid) valve, which has 3 cusps, and the L atrioventricular (bicuspid) valve, which has only 2 cusps (also called mitral valve).
How do atrioventricular valves prevent the back flow of blood into the heart?
When the ventricles start to contract, the pressure within them rises and forces the blood superiorly against the valve cusps pushing the edges of the cusps together and closing the AV valves.
Pectinate muscles:
A smooth-walled posterior part and an anterior part lined by horizontal ridges.
Chordae tendineae:
Thin strong bands (the heart strings); project superiorly from the papillary muscles to the flaps (cusps) of the tricuspid (R atrioventricular) valve.