Lecture 9: Enterovirus & Adenovirus Flashcards
PicoRNAviridae
-genome
-envelope
-capsid
Smallest viruses
-(+) RNA
-no envelope (naked = resistant to harsh)
-icoshedral capsid
Picornaviridae types
-enterovirus
-hepatovirus
-genome
-envelope
-poliovirus (entero)
-enterovirus (entero)
-Coxsackievirus (entero)
-Echovirus (entero)
-Rhinovirus A, B, and C (entero)
-hepatitis A (hepatovirus)
entero = comes from the virus ability to infect intestinal tract and shed virus w/o GI diseases
-genome = (+) ssRNA
-envelope = naked
Picornaviridae pathogenesis (general)
-where does the virus shed?
Enterovirus replication in the OROPHARYNX
Then primary VIREMIA
TARGET TISSUE
-liver = HAV = Hepatitis
-Meninges = Echo, polio, Coxsackie = Meningitis
-brain = Polio, Coxsackie = Encephalitis or paralytic disease
-muscle = Echo, CAV & CBV = heart or thorax = myocarditis or Pleurodynia
-skin = Echo, CAV = (HFMD) = Rash
Then secondary VIREMIA
-virus shed in stool
Coxsackie A virus (CAV)
-capsid
-genome
-envelope
-occurs mostly in
Icosahedral
(+) ssRNA
Naked
-children <5 (incidence increase during school)
CAV transmission (coxsackie A)
-fecal-oral route
-aerosol droplets
-direct contact/fomites
CAV (Coxdackie A virus) can cause:
-Hand-foot-mouth disease = fever + painful blisters in palms/soles/cheeks/ hard palate/ throat/ tongue/ gums/
-Herpangina = sores appearing in the back of the mouth or throat
-Hemorrhagic Congunctivitis = pink eye
Hand-foot-mouth disease (HFMD)
-caused by?
-contagious?
-symptoms?
-caused by CAV (enterovirus)
-highly contagious
-lesions first appear in the anterior portion of mouth before appearing on the skin
fever + painful red blisters in throat, tongue, gums, hard palate, cheeks, palms, and soles
Herpangina
-caused by?
-symptoms?
-CAV (enterovirus)
-painful blisters in the back of the throat and palate (last 1 week)
-3-10 yoa
Acute Hemorrhagic Congunctivitis
-caused by?
-symptoms?
- KNOWN AS “PINK EYE”
-CAV (Enterovirus)
-lid swelling
-mucoid discharge becomes watery
-photophobia
-rapid incubation (sudden onset in ONE eye)
-results in EPIDEMICS (highly contagious)
Diagnosing of CAV!
-how would you diagnose the difference between/w Herpangina vs. HSV diagnosis
Clinically
*Herpangina = generally causes ulcers in the BACK portion of the mouth (soft palate)
*HSV = ulcers in the hard palate, gums, tongue
Treatment for CAV (coxsackie A virus)
Supportive care only
Adenovirus
-capsid
-genome
-envelope
-how do Adenoviruses differentiate between Enteroviruses?
-Icosahedral
-dsDNA
-naked
-Adenovirus = dsDNA vs. Enterovirus = (-) ssRNA
The enteroviruses are a genus of the family picornaviruses and can infect the intestinal tract and shed the virus into feces w/o causing GI diseases. Adenoviruses is a family and causes GI infections
Adenovirus
-most common disorders
-most common isolated
-most common cause
-URT, eye, GI infections, epidemic Keratoconjunctivitis (EKG)
-isolated in children and infants from pharynx and stools
-most common cause
Most common cause of viral conjunctivitis
Adenoviruses
Adenovirus transmission
-aerosols
-fecal
-direct contact (fomites, fingers, swimming pools)
*can usually last for up to 5 weeks on inanmiate objects) this is fairly common on naked viruses