Lecture 9 Bone (Connective Tissue III) Flashcards
What are the functions of bone?
Provide support for the body
Protecting vital organs
Cavity for bone marrow for blood formation
Important reservoir for calcium and phosphate + other ions
Work with the muscular system for body movement – system of levers
—> Mechanical + metabolic functions to the skeleton
What are the 3 major cell types of bone?
osteoblast, osteoclasts, osteocytes
______ live in lacunae but have cytoplasmic processes extending out through canaliculi
osteocytes
______ synthesize ECM - surface of bone – osteogenic
osteoblasts
______ are multinucleated giant cells – derived from monocytes – reabsorb and remodel bone
osteoclasts
Label the diagram
Ob = osteoblast
Oc = osteoclast
Os = osteoid (less eosiniphillic)
M = mesenchyme
B = bony matrix
Label diagram, What stain is this?
Ocl = osteoclast (remodel)
Oc = osteocyte (trap)
ob = osteoblast (periphery)
Mallory’s trichrome
True or False: Osteoblasts secrete osteoid
True
_____ are the vein structures in the picture, _____ is known as the cavity in the cell body
canaliculi (ground bone), lacunae
What do osteocytes in lacunae do?
mobilize or deposit Ca2+, skeleton is a Ca2+ store
- Detect stress to signal remodeling of the bone
______ use a acidic environment to dissolve bone.
Acid
_____ makes up 80% of the bone and is found at the periosteum where ____ makes up 20% of the bone and is fone in the endosteum. They are both lamellar bone
Compact and cancellous bone
How do osteoclasts remodel bone?
Tunneling
How does ossification of flat bones work?
ossification centre in tissue, bone matrix (osteoid) secreted in membrane, woven bone and periosteium form, bone collar from compact bone and red marrow appears
Ossification of flat skull bone takes place within condensations of ______.
embryonic mesenchyme
Primary ossification center increases _____ while secondary increases ______.
thickness, length
______ (C) are basophilic and devoid of chondrocytes and become enclosed by more lightly stained osteoid and ______ (B) produced by active ______ (O).
Calcified cartilage matrix, woven bone, osteoblasts
What occurs during each zone of the epiphyseal plate?
Zone 1, resting cartilage
2, proliferating cartilage
3, calcifed carilage
4, ossification
How does bone repair work?
Hematoma, fibourus cartilage forms, woven bone (callus), bone is remodeled
What is the synovial membrane derived from?
B cells = mucopolysaccharides
(hyaluronan) –> lubricant
