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BI 330 Fundamentals of Histology > Lecture 7 Connective Tissue I > Flashcards

Lecture 7 Connective Tissue I Flashcards

1
Q

What is connective tissue?

A

Supports and connects other tissue (parenchyma) and forms a matrix that maintains form/shape of the organ

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2
Q

WHat are the functions of connective tissue?

A

transport (vascularized – blood supply) Mechanical support Growth & repair Hemochoasis (blood cell synthesis) Energy economics (fat, adipose tissue)

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3
Q

______ and ______ make up the ECM

A

protein fibers and ground substance

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4
Q

What are the 4 cellular components of CT?

A

fibroblast, adipocyte, macrophage, mesenchymal cell

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5
Q

What is the origin of CT?

A

Embryonic mesenchyme

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6
Q

______ have large nuclei in cells, euchromatic, tend to have a prominent nucleolus and surrounded by an ECM that they produced and that consists largely of a simple ground substance rich in hyaluronan with very little collagen.

A

Embryonic mesenchyme

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7
Q

What are the 6 types of CT tell types?

A

fibroblasts, macrophages, mast cells, plasma cells, adipocytes, leukocytes

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8
Q

_____ are active cells with lots of collagen and spindle shaped nucleus.

A

Fibroblasts

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9
Q

What does this image depict?

A

Active and inactive fibrocytes

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10
Q

Fibroblasts involved in wound healing call ______. Contractile. Pull edges of the wound together by contraction like smooth muscle.After role completed, undergo ______

A

myofibroblasts, apoptosis

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11
Q

_______ are derived from monocytes and have a prominent nucleus as well as a lot of lysosomes. Also, have antigen presentation for immune response.

A

Macrophages

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12
Q

______ are derived from progeniture cell in bone marrow, take up residency in CT and play a role in inflammation. Use a metachromatic stain.

A

Mast cells

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13
Q

True or False: Mast cell secretion is triggered by re-exposure to certain antigens and allergens (ie, bacteria)

A

True

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14
Q

______ are antibody-secreting plasma cells, derived from b-lymphocytes, very active (RER–Golgi), basophilic

A

Plasma cell (can see Golgi ghosts in cell)

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15
Q

What are the 3 fiber types?

A

Collagen, reticular, elastic

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16
Q

What percent of protein in your body is collagen?

17
Q

_____ 28 different types, resistant to tears and shearing forces, a key element to the basement membrane

18
Q

______ are elongated components of the connective tissue of CT, that are formed as precursors that polymerize externally and not formed in cell

19
Q

______ are delicate connective tissue, form networks

20
Q

_____ aid in providing resiliency to connective tissue.

A

Elastic fibers

21
Q

90 % of collagen is ______, acidophilic/eosinophillic, extremely strong and forms bundles

22
Q

What type of assembly does Type I collagen form?

A

Triple helix

23
Q

_____ form stroma and lattices/networks, high in carbohydrate (PAS) but see well with silver stain

A

Reticular fibers

24
Q

______ is a thinner Type I collagen, that stains poorly with H&E and better with aldehyde fuchsin (ex, dermin and aorta)

A

Elastic fibers

25
Q

True or False: When stretched, elastic binds with less steric hindrance

26
Q

______ is highly hydrated and transparent, a complex mixture of macromolecules.

A

ground substance

27
Q

What are the 3 types of ground substance?

A

Glycosaminoglycans (GAG)

Proteoglycans

Multi adhesive glycoproteins

28
Q

What are examples of glycoproteins and proteoglycans?

A

Glyco- More protein than carb, Oligosaccharides, Multi adhesion proteins

Proteo - carb than protein, Polysaccharides, GAG glycosaminoglycan = mucopolysaccharide, Hyaluronic acid most common, binds a lot of water

​

29
Q

_____ is a multi adhesive protein present in the basal lamina, a binding site for integrins (epithelial cell) + matrix macromolecules

30
Q

_____ is a multi-adhesive protein, binds to GAG, found throughout CT

A

Fibronectin

31
Q

what are the 4 types of proper connective tissue?

A

Loose, Dense (regular, irregular), reticular, mucoid

32
Q

This picture illustrates what type of connective tissue? (dense w/ less GS)

A

Dense regular

33
Q

______: high fiber

  • Irregular orientation, eg, dermis of skin (picture b)
  • Collagen blue trichrome stain
  • Sheer forces from different directions = irregular orientation

______: less fiber, less dense between DI + epithelium

  • Well vascularized (b/c epithelium not, needs nutrients and blood supply somehow)
  • Delicate
  • More GS

​

A

Dense irregular, Loose CT

34
Q

This is an example of what kind of connective tissue? (silver stain)

35
Q

______ tissue is, similar to embryonic mesenchyme, Very loose ECM, Little fibers, No eosin staining of collagen, Mainly GS, Very watery tissue, HYALURONAN = gelatinous

BI 330 Fundamentals of Histology (10 decks)

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