Lecture 9- Blood and hemostasis

Question 1

the availability of dietary iron can be a limiting factor in …. so storage and recycling mechanisms are highly developed in humans to protect from…

Answer 1

erythropoiesis

anemia

Question 2

… serves as a storage buffer for iron

Answer 2

ferritin

Question 3

RBS life span… meaning …% of RBC replaced daily

Answer 3

120 days

1%

Question 4

… is major breakdown product of hemoglobin

Answer 4

bilirubin

Question 5

iron released from detroyed RBC is bound by… and delivered to bone marrow

Answer 5

transferrin

Question 6

Folic acid is needed for…. if deficient then there is impaired…

Answer 6

thymine

cell division

Question 7

… is required for action of folic acid. … absorption requires… so if there is no… then you get … anemia

Answer 7

B12
B12
intrinsic factor
intrinsic factor
pernicious

Question 8

Erythropoiesis regulation: if there is decreased … delivery to the kidney then this causes the secretion of … which activates receptors in the …. leading to an increase in the rate or erythropoiesis

Answer 8

O2
erythropoietin
bone marrow

Question 9

5 causes of anemia

Answer 9

1. dietary (B12/folic acid)
2. kidney disease (inadeq. secretion of erythropoietin)
3. hemorrhage
4. bone marrow failure due to drugs or cancer
5. excessive destruction of erythrocytes