Lecture 5- Growth and diabetes

Question 1

… is necessary for fetal growth and … becomes more important later in life

Answer 1

IGF-1

GH

Question 2

… hormone is require for synthesis of GH and manifestation of GH effects

Answer 2

thyroid

Question 3

growth is also controlled by glucose regulating hormones, …. inhibit GHRH secretion and …. actions oppose GH and IGF-1

Answer 3

glucocorticoids

insulin

Question 4

gonadal steroids… and … also have a role in growth

Answer 4

T

E2

Question 5

at puberty, the epiphyseal plates ossify due to the actions of …

Answer 5

E2

Question 6

there are 2 hypothalamic hormones that regulate GH secretion

Answer 6

GHRH

Somatostatin

Question 7

GH is a mitogen meaning it will stimulate … and it also acts in muscle and bone to stimulate…

GH’s actions are in opposition to…

Answer 7

cell division

protein synthesis

Question 8

the principal indirect effect of GH on growth is to stimulate the secretion of… from the liver and other tissues

Answer 8

IGF-1

Question 9

IGF-1 and GH inhibit … and … secretion but stimulate … secretion

Answer 9

GH
GHRH
SS

Question 10

what are 5 stimuli to GHRH secretion

Answer 10

fasting
low glucose
stress
sleep
exercise

Question 11

are there any known defects in IGF-1 synthesis or for the IGF-1 receptor?

Answer 11

no

Question 12

excess production of GH results in … and… this is typically caused by a pituitary tumor

Answer 12

gigantism

acromegaly

Question 13

… results from prepubertal onset of excess GH.

… results from a postpubertal onset excess of HG

Answer 13

gigantism

acromegaly

Question 14

… is reduced growth due to constitutive activation of the fibroblast growth factor receptor

Answer 14

achondroplasia