Lecture 9 Flashcards
Whether a neurotransmitter is excitatory or inhibitory
Depends on the properties of its receptors
A simple reflex behavior
- stim of the mantle or siphon leads to gill withdrawal
- this reflex habituates with repeated stimulation
- this reflex can also be enhanced, or sensitized, in response to a novel stimulus
The reduction/enhancement of the motor-neuron Excitatory Post Synaptic Potentials (EPSPs)
Mirrors the behavioral habituation/sensitization
Sensitization involves a
secondary facilitating interneurons
Short-term Habituation
Occurs from a reduction in neurotransmitter releases by the sensory neuron
Short-term Sensitization
Occurs from an increase in neurotransmitter release as a result of presynaptic facilitation
Long-term Sensitization
Can occur if kinase activity elicits changes in sensory neuro-protein synthesis
Long-Term Neuromodulation: Potentiation
Tetanic Stimulation of neurons in the hippocampus leads to an increase in EPSPs
Synaptic Plasticity:
- Modify the strength of the connection between 2 neurons
- Modify nt release rate of syntheses
- adjust Post-Synaptic Sensitivity
Synaptic Plasticity: Modify the Strength of Connection Between 2 Neurons
The amp of post-synaptic potential
Synaptic Plasticity: Modify nt release rate of syntheses
- regulate Ca 2+ Concentration
- Build new presynaptic terminals
- use modulators
Synaptic Plasticity: Adjust post-synaptic Sensitivity
- Recruit different receptors
- Add/Remove receptors
- Change size