Lecture 12

Question 1

What do Muscles need ATP for?

Answer 1

Contraction and relaxation

Question 2

What 3 Metabolic Pathways Supply the ATP:

Answer 2

1. Creatine phosphate
2. Glycolysis
3. Oxidative phosphorylation

Question 3

Creatine Phosphate (CP) and ATP (4)

Answer 3

1. ATP synthesis rate - very fast
2. Yeild of ATP - Very low
3. Primary Fuel - Muscle CP
4. Limitations: Short duration

Question 4

Glycolysis and ATP:

Answer 4

1. ATP synthesis rate - fast
2. Yeild of ATP - low
3. Primary Fuel - Muscle glycogen
4. Limitations: Low efficiency, lactic acid build-up

Question 5

Oxidative Phosphorylation - Myoglobin O2 and ATP:

Answer 5

1. ATP synthesis rate - fast
2. Yeild of ATP - Very high
3. Primary Fuel - Muscle glycogen
4. Limitations: Short duration

Question 6

Oxidative Phosphorylation - Environmental O2 and ATP:

Answer 6

1. ATP synthesis rate - slow
2. Yeild of ATP - Very high
3. Primary Fuel - blood glucose and fatty acid
4. Limitations: O 2 delivery is gradually increased (ie. breathing &
   circulation)

Question 7

Genetic Engineering and the Physiological Role of Creatine Kinase (Hypothesis):

Answer 7

Creatine phosphate serves as a principal source of ATP during the first seconds of burst exercise

Question 8

Genetic Engineering and the Physiological Role of Creatine Kinase (Prediction):

Answer 8

Lowering the levels of creatine kinase (CK) should interfere with burst exercise

Question 9

Genetic Engineering and the Physiological Role of Creatine Kinase (Methods):

Answer 9

Generate mice mutants with different muscle CK enzyme activity, and then compare the ability of their muscles to perform burst activity

Question 10

Genetic Engineering and the Physiological Role of Creatine Kinase (Results):