Lecture 8.3: Pain

Question 1

Pain perception occurs in the

Answer 1

cerebrum

Question 2

Cell bodies of nociceptors in the region of the head and face sit in the

Answer 2

trigeminal ganglion

Question 3

Peripheral nociceptors transduce noxious stimuli into

Answer 3

action potentials

Question 4

True or false:

Peripheral nociceptors generally have quite fast conduction velocities.

Answer 4

False, they have relatively slow conduction velocities.

Question 5

Properties of Aδ-fibre axons

Answer 5

Thinly myelinated
Conduction velocity 5-30 m/s
Fast (sharp) pain

Question 6

Properties of C-fibre axons

Answer 6

Unmyelinated

Conduction velocities

Question 7

TRPV-1 responds to which types of stimuli

Answer 7

noxious heat, acid and capsaicin

Question 8

2nd order neurons for the body ascend in the

Answer 8

contralateral spinal cord

Question 9

2nd order neurons for the face ascend in the

Answer 9

trigeminothalamic tract

Question 10

True or false:

Sensitisation is based on the resulting increased pain characteristics to normal stimulus.

Answer 10

False, the term sensitisation is based on the physiology of the receptor, not the pain characteristics.

Question 11

Hyperalgesia

Answer 11

Increased pain from a stimulus that normally provokes pain

Question 12

Allodynia

Answer 12

Pain due to a stimulus that doesn’t usually invoke pain

Question 13

Neurogenic inflammation

Answer 13

Release of inflammatory mediators by peripheral nociceptors that produce or exaggerate local tissue inflammation