Lecture 10.1-10.3: Nervous System Disorders

Question 1

PCP (angel dust) is a drug that causes psychotic states with similarities to schizophrenia acts on which type of receptors

Answer 1

PCP acts on glutamate receptors, rather than dopamine. This goes against the dopamine hypothesis for schizophrenia.

Question 2

Multiple Sclerosis is a chronic, autoimmune disease characterised

Answer 2

destruction of myelin in the CNS

Question 3

Regions involved in movement disorders

Answer 3

Cerebellum and basal ganglia:

• Dorsal striatum (caudate nucleus and putamen)
• Ventral striatum (nucleus accumbens and olfactory tubercle)
• Globas pallidus, ventral pallidum, substantia nigra, subthalamic nucleus

Question 4

Main GABAergic projection neurons of the striatum

Answer 4

Medium spiny neurons (MSNs)

Question 5

Medium spiny neurons express which type of receptor

Answer 5

Dopamine

Question 6

NL3 Mutations in mice can cause

Answer 6

– increased aggression (reversed by risperidone)
– reduced vocalizations in early development (postnatal day 8)
– both NL3-R451C and NL3-KO mice show improved motor learning (Rothwell et al., Cell, 2014)

Question 7

Which type of NL3 mutated neurons exhibit elavated fine motor control?

Answer 7

D1 medium spiny neurons