Lecture 8- Physiology of hearing and balance Flashcards

1
Q

Components of the outer ear

A

Pinna (auricle), ear canal, tympanic membrane

Directs sound to tympanic membrane ( eardrum)

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2
Q

Components of middle ear

A

Ossicular level system
Malleus (hammer), incus (anvil), stapes (stirrup), as well as tensor timpani and stapedius muscles
Transmits vibrations from the tympanic membrane to the inner ear

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3
Q

Components of the inner ear

A

Cochlea- hearing
Vestibule + semicircular canals- balance
conversion of mechanical vibrations to electrical signals in cochlear nerve

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4
Q

Middle ear functions- Critical damping

A

Tympanic membrane vibrates at same frequency as sound waves on its surface-attached to 3 bones and 2 muscles (attached to ossicles)
Activated before speaking or on hearing loud sounds (pre-programmed/ reflexive)

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5
Q

Middle ear functions- amplification

A

Related to impedance matching- sound pressure arriving at oval window increaed due to lever action of anvil and hammer and because area of tympanic membrane >oval window- force multiplied by 35%

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6
Q

Middle ear functions- impedance matching

A

Inner ear membranes operate in a fluid medium and so amplification needed to vibrate them- fluid has greater impedance than air which makes it difficult to vibrate
Weak vibrations of large area of eardrum in air magnified by ossicles/concentrated into strong vibrations over oval window to displace fluid
Matches impedance in air (outer) vs fluid (inner) environments

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7
Q

What are the 3 chambers of the cochlea?

A
Scala vestibuli
Scala timpani ( continuous and contain perilymph, rich in Na+)
Scala media- contains endolymph, rich in K+
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8
Q

Inner ear functions

A

Conversion of mechanical signal arriving at cochlea via oval window into electrical signals to register in auditory cortex as sounds
Mechanical vibrations move basilar membran, converted to electrical by hair cells imbedded in it. (3/4 rows of outer HC, 1 inner)

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9
Q

Where do afferent and efferent fibres of the cochlear nerve go?

A

90% of afferent come from IHC (as they are main transducers of mechanical vibration into nerve impulses)
Most efferent go to OHC, elucidating function as modulators of sensitivity of IHCs

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10
Q

How is tectorial membrane and basal lamina organised and how does it impact function?

A

They are arranged so vertical vibrations of basilar membrane are converted to lateral motion of hair cells.
As hairs vibrate laterally, filmaents linking adjacent HCs open ion channels, allowing K+ to enter and depolarise hair cells.
APs set up in VIII CN, potassium enters hair cell and is recycled into endolymph via stria vascularis.

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11
Q

Where is the human auditory complex located?

A

Superior portion of temporal lobe, embedded within sylvian fissure.
Contains map of frequencies- high and low at different ends

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12
Q

What shape is the primary auditory cortex?

A

Effectively a topographical columnar map of the basilar membrane, each of which repeated several times (diff sounds picked up on diff locations)
Assc. areas found close to prim AC, associating sounds with other somatosensory information

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13
Q

Brocas vs Wernicke’s area

A

Wernickes- cmoprehension of speech- gibbberish, fluent jargon or Wernicke’s aphasia)
Brocas- production of speech sounds- De Broca’s/ non-fluent aphasia

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14
Q

Sensorineural vs conductive deafness

A

Impaired sound conduction from pinna to inner ear (conductive)
Damage to hair cells/ neural pathways (sensorineural)

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15
Q

Conductive deafness- causes

A

ear wax in ear canal, perforated eardrum (common in sport diving and with v. loud sounds), fluid in middle ear w/ infection or damaged ossicles (disease/loud sounds)

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16
Q

Sensorineural deafness causes

A

Loud sounds- hair cells sheared and not regenerated- very loud sounds can rip basilar membrane
Some antibioitcs (strepta/gentamycin) can enter channels of hair cells and disrupt their function- degeneration > deafness
Tumours in auditoru nerves/ vascular damage to medulla also results in deafness

17
Q

Inner ear and balance

A

Semicircular canals and vestibule (utricle and saccule)
2 pairs of 3 semi-circular canals detect rotational acceleration in planes XYZ
Utricle detects- linear accelerations in vertical plane
Saccule detects- linear accelerations in horizontal plane

18
Q

Semicircular canals

A

Ampulla is at base of each SCC- crista ampullaris within it which mounts hair cells, whose processes are found in cupula
Head rotates > fluid within SCC moves relative to labyrinth and displaces cupula
Have non motile hair, as others hairs bend towards they increase discharge in nerve- bend away reduces firing rate.
At start of rotation FR increases, and discharge rate decreases as bent back other way- changes in rotational acceleration signalled to brain

19
Q

Utricle and saccule

A

on the floor of both is the macula, an otolithic organ.
Overlying hair cells is a gelatinous layer in which is embedded crystals of calcium carbonate (otoliths or ear dust)
If hairs move towards kinocilium they increase nerve discharge rate, moving them from KC decreases impulse generation

20
Q

CNS projections and balance

A

vestibular nucleus of medulla to cerebellum (balance and setting background against predicted rapid movements can take place)
2. spinal cord via VS tract to muscles involved in maintaing eqm
3. reticular formation, general arousal and inc. conduction speed/ sensitivity in all motor nerve pools
4. upward connections to eqm cortex in sylvian fissures opposite hearing area
Important for conscious sensations of eqm and vestibule ocular reflex (VOR)/ nystagmus

21
Q

Nystagmus

A

pursuit movement of the eye during head rotation where eye fixates on single object and flicks back to its original position when eye has reached limit of rotation.
Controlled by semicircular canals