lecture 8/9 redone

Question 1

in CF you cant reabsorb sodium chloride causing sweat to be

Answer 1

salty

Question 2

what is N in N x Po x i

Answer 2

N - increase the number of CFTR channels at the surface (class II)

Question 3

Po

Answer 3

improve CFTR channel gating - how long the channel is open for (class III)

Question 4

i

Answer 4

increase ion flux - amount of chloride ions passed through the channel (class IV)

Question 5

what are the 2 types of CFTR modulators

Answer 5

potentiators and correctors

Question 6

what do potentiators increase

Answer 6

gating (e.g G551D channel activity)

Question 7

correctors

Answer 7

promote processing of class II mutants to plasma membrane (e.g. f508del)

Question 8

example of potentiator

Answer 8

e.g VX-770 (ivacaftor)

Question 9

example of corrector

Answer 9

VX-809 (lumacaftor)