lecture 25 redone

Question 1

robust beta cells increase insulin secretion

Answer 1

susceptible beta cells become dysfunctional

Question 2

target carbohydrate absorption
enzymes that break down carbohydrates have

Answer 2

alpha glucosidase activity

Question 3

inhibitors of this enzyme have been used to inhibit breakdown

Answer 3

AGIs alpha glucosidase inhibitors

Question 4

AGIs can cause discomfors because indigested carbohydrates pass from

Answer 4

SI to colon

Question 5

targeting renal glucose excretion (more glucose in urine)
SGLT inhibitors prevent reabsorption of glucose causing

Answer 5

excretion in urine

Question 6

increase risk of UTIs

Question 7

target insulin secretion
sulphonylureas bind to SUR1 in the potassium ATP channels of beta cells, its an agonist can caused the channel to close therefore more insulin is secreted

Question 8

targeting insulin secretion
incretin receptors
incretin = intestinal peptides produces in reponse to food and they stimulate insulin release

Answer 8

eg GIP and GLP-1

Question 9

DPP4 inhibitors would increase half life od GLP-1

Answer 9

secretes insulin depending on blood glucose levels

Question 10

metformin targets the liver

Question 11

PPAR gamma drugs favour adipocyte prliferation

Answer 11

eg TZDs
histon acetylase causes exposure of chromatin
in creases transcription