lecture 7 training adaptions to training part 1

Question 1

what type of reaction is LDH

Answer 1

near

Question 2

1 Classic adaptations to training

Answer 2

1. training increases maximal activity (Vmax) of
   mitochondrial enzymes in rat skeletal muscle

Question 3

2 Classic adaptations to training

Answer 3

Training increases mitochondrial protein content
a. Concentration of cytochrome c
b. Amount of mitochondrial protein
– More “respiratory chains” (i.e., ETC
complexes) per gram of mitochondria

Question 4

3 classic adaptations to training

Answer 4

Training increases the ability of isolated
mitochondria to consume O2

Question 5

functional effect of endurance training

Answer 5

1. increased exercise capacity
   - time to exhaustion
2. increase exercise performance
   - time trial

Question 6

metabolic effects of endurance training

Answer 6

1. reduced muscle blood lactate accumulation
2. reduced CHO utilization
3. increased fat oxidation

Question 7

spreading the load

Answer 7

1. increased oxidative capacity of untrained type 2 fibers
2. increased mitochondria in all fibers

Question 8

What is the primary regulator of mitochondrial respiration?

Answer 8

ADP

Question 9

ADP vs. mitochondrial respiration curve

Answer 9

linear increase

Question 10

training adaption

Answer 10

• spreading the load amongst more mitochondria*
• more mitochondria= less need to drive ADP up to stimulate mito in new state

Question 11

What enzymes or metabolic processes would
be affected by lower intramuscular [ADP] and
[AMP] during exercise

Answer 11

1. Reduced stimulation of glycolysis through PFK
2. Reduced stimulation glucose uptake through
   AMPK
3. Reduced lactate accumulation through
   mitochondrial pyruvate uptake (PDH)
4. Reduced H+ accumulation leading to enhanced
   fat oxidation via less CTP1 inhibition