Lecture 7: Hormones, Behaviour & Stress Flashcards
Define hormone
Any molecule that gains access to blood stream and travels far distance. Reaches widespread targets to produce behaviour. Release is governed by brain in response to sensory info. Once released, they loop back to brain to inform to stop secreting
Two classes of hormones
Steroids or peptides
Describe steroid hormones
Testosterone, cortisol, etc
Fat soluble and can cross cell membrane to talk dna to increase or decrease protein production. Produced in various endocrine glands
Describe peptide function
Produced in the cell, examples are grehlon, insulin, endorphins. Influence cells to activate metabotropic receptors, can affect cell physiology
List and describe three groups of hormone function
Homeostatic : internal metabolic balance
Gonadal: sexual behaviour, gender, regulate mentrual cycle
Glucocorticoid : secreted during stress, controls blood sugar
What are homeostatic hormones?
Maintain body’s essential internal environment such as blood sugar, blood pressure, heart rate, temperature, etc
What are gonadal hormones?
Sex hormones which prepare us for adulthood, give sexual appearance, allow for sexual behaviours
What are glucocorticoids?
Regulate glucose, and the adrenal cortex.
Define stress
Physiological and psychological response generated to perceived threat
Describe fast stress response
- Hypothalamus sends message to adrenal medulla via spinal cord
- Adrenal medulla stimulate release of epinenphrine
- Epinenphrine stimulates cells, endocrine glands, brain
Describe slow response
- Hypothalamus releases CRH to pituitary gland
- Pituitary gland releases ACTH which goes to adrenal cortex
- Adrenal cortex releases cortisol
- Cortisol activates body’s cells, endocrine glands and brain
What is a negative feedback loop?
When a hormone travels back up to the anterior pituitary via the blood stream, further activation is ceased.
List some symptoms of chronic stress ( describe the maladaptive stress response)
- muscle wasting and fatigue because of continuous mobilization of energy
- little growth because growth hormone inhibition
- GI tract shut off
- reproductive functions inhibited
- immune system suppressed
- desensitization of negative feedback loop allows for continuation
In what brain region does chronic stress and high cortisol demonstrate atrophy?
Hippocampus
What are two major effects of synthetic steroid use?
Muscle building (anabolic) Masculinizing (androgenic)