Lecture 7 Crohn’s Disease, IBS and UC

Question 1

Name 5 features of Crohn’s

Answer 1

No blood or mucus
Enture GI tract
Skip lesions
Terminal ileum most affected
Smoking is a risk factor

Question 2

Name 7 features of Ulcerative Colitis

Answer 2

Continuous inflammation
Limited to colon and rectum
Only superficial mucosa affected
Smoking is protective
Excrete blood and mucus
Use aminosalicylates
Primary sclerosing cholangitis

Question 3

What are the presenting symptoms of Crohn’s

Answer 3

Weight loss
Growth failure
Abdominal pain
Anaemia

Question 4

What are the symptoms of Ulcerative Colitis

Answer 4

Diarrhoea
Rectal bleeding
More common in adults
Anaemia
Abdominal pain

Question 5

Name extra-intestinal manifestations seen in IBD

Answer 5

Finger clubbing
Erythema nodosum
Inflammatory arthritis

Question 6

How is IBD diagnosed

Answer 6

Faecal calprotectin
Raised CRP
Endoscopy
Imaging: CT, MRI

Question 7

What are the first line treatment for Crohn’s

Answer 7

Steroids (oral prednisolone or IV hydrocortisone)

Add immunosuppressant (Azathioprine, methotrexate)

Question 8

What is the next step up of treatment from Immunosuppressants in the treatment of Crohn’s

Answer 8

Biologics (Infliximab)

Question 9

If medication doesnt work for Crohn’s what is the next option

Answer 9

Surgery

Question 10

What is the first line treatment for UC

Answer 10

Aminosalicylate

Question 11

What is the second line treatment for UC

Answer 11

IV corticosteroids

IV ciclosporin