Lecture 7

Question 1

Alpha1-adrenoceptor

Answer 1

Phenylephrine and oxymetazoline

Question 2

Beta2-adrenoceptor

Answer 2

Salbutamol, terbutaline, salmeterol

Question 3

Beta1-adrenoceptor

Answer 3

dobutamine

Question 4

Beta 1 selective

Answer 4

atenolol (arrhythmias).

Labetolol (hypertension)

Question 5

What are the Muscarinic Agonist?

Answer 5

Carbachol, methacholine, bethanecol, muscadine, pilocarpine, oxotremorine

Question 6

What are Muscarinic Antagonist

Answer 6

Atropine (anaesthesia, GI hypermotility) Hyoscine (motion sickness) Ipratropium (asthma) Tropicamide Pirenzapine (peptic ulcer)

Question 7

Edrophonium

Answer 7

Diagnosis of myasthenia gravis Too short acting for therapeutic use

Question 8

Neostigmine

Answer 8

Used to reverse competitive neuromuscular block. Used orally in treatment of myasthenia gravis. - visceral side-effects

Question 9

Physostigmine

Answer 9

Eye drop in the treatment of glaucoma

Question 10

Pyridostigmine

Answer 10

Orally in treatment of myasthenia gravis. Better absorbed than neostigmine Longer duration of action

Question 11

Dyflos

Answer 11

Highly toxic organophosphate Prolonged action Eye drop for glaucoma

Question 12

Ecothiopate

Answer 12

Eye drop in treatment of glaucoma. Prolonged action; systemic effect

Question 13

Parathion

Answer 13

Converted to active metabolite by replacement of sulfur by oxygen Used as insecticide - causes poisoning in humans