Lecture 6- Lipids(fats) Flashcards

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0
Q

Functions of lipids

A
  • provide energy: at rest, fasting and during moderate intensity excercise, prolonged excercise
  • energy storage
  • padding (protection) and insulation
  • component of the cell membrane
  • synthesizes compounds
  • absorption and transport fat-soluble vitamins
  • satiety
  • flavor and mouthfeel (the texturethat the food has in your mouth
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1
Q

Lipid molecule

A
  • structure C, H, O
  • does not dissolve in water
  • 3 type of lipids in food:
    • triglycerides (TG)
    • phospholipids
    • sterols
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2
Q

Triglycerides

A
- three fatty acid molecules
   • carboxylic acid, COOH, alpha end
   • methyl, CH3, omega end
- one glycerol molecule
   • glycerol is an alcohol (COH)
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3
Q

Fatty acids facts

A
- fatty acids vary by: 
   • chain length
   • degree of saturation
   • structure of carbon bonding
   • variation impact fatty acid properties 
- TG (and foods) are comprised of a mixture of fatty acids 
- some fatty acids are essential
- some are better or us than others
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4
Q

Fatty acids: Chain length

A
  • short chain FA: fewer than 6 carbons
  • medium chain FA: 6-12 carbons
  • long chain FA: 14 or more
  • shirt and medium FA chains get directly absorbed into circulation, liquid at room temperature
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5
Q

Fatty acids: degree of saturation

A
  • saturated: no double bond
  • monounsaturated: one double bind
  • polyunsaturated: 2 or more double bond
  • mono an poly= UFA (unsaturated fatty acids)
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6
Q

Fatty acids: structure of C bonding

A
Double vond can be found in: 
- cis: kink
    • H on same side
- trans: linear
    • H on opposite side 
- impacts shape and fluidity
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7
Q

Partially hydrogenated fatty acids (trans fat)

A

What:
- H added under pressure= H opposite side C chain

Why:

- pack= more solid
- less prone to become oxidized (rancid)
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8
Q

Essential fatty acids

A
  • 18 C long omega 3&6 are essential
  • linoleic acid: omega 6
    • most vegetables oils, nut oils
  • alpha linolenic acid: omega 3
    • canola and soybean oil, flaxseed oil, walnuts
    • cold water fish oils are a source of EPA and DHA
    • omega 3 associated with reduced heart disease
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9
Q

Essential fatty acids metabolize to….

A
  • metabolize to longer FA
  • precursors of Eicosanoids
    • hormone like properties that regulate cellular functioning (prostaglandins, thromboxanes, leukotrienes)
    • “local hormones”
    • eisanoids from omega 3s reduce inflammation, blood clotting and acts as vasodialators (favorable, heart healthy)
  • blood clotting, vasoconstriction/ dilation, inflammation, immune function, and other body process
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10
Q

Saturated fats

A
  • bad
  • raises LDL cholesterol and HDL cholestetol
    (LDL is really bad, risk factor for a lot of heart disease; HDL is a good thing)
  • coconut, palm, palm kernel oil, butter, cream, cheese, beef fat, whole milk
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11
Q

Trans fatty acids

A
  • extremely bad
  • raise LDL cholesterol, and lowers the the HDL cholesterol
  • margarine, crackers, cookies, fried-foods
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12
Q

Monounsaturated

A
  • good
  • reduces LDL cholesterol, and POSSIBLELY raises HDL cholesterol
  • olive oil, canola oil, peanut oil, cashew nuts
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13
Q

Polyunsaturated

A
  • good (some better than others)

- vegetable oils, fish oils, canola, cottonseed

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14
Q

Saturated Fat Needs

A
  • AMDR: 20-35% Kcals
  • general recommendations:
    • saturate fat:
    ~ dietary guidelines: <7%
    ~ 20 g saturated fat (AHA: 15g)
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15
Q

Trans fat needs

A
  • as low as possible, <2g on a 2000 kcal diet)

• current intake ~ 3% kcals

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16
Q

Adequate intake for EFA

A
  • linoleic: most meet with no problem
  • alpha-linolenic acid: less often met
    • men (19-50yrs): 1.6g/d
    • women (19-50yrs): 1.1g/d
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17
Q

Phospholipids structure

A
  • glycerol
  • 2 fatty acids
  • phosphate containing molecule
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18
Q

Phospholipids

A
  • properties: hydrophobic and hydrophilic ends
  • liver makes phospholipids (not essential)
  • foods: animal cell membranes, egg yolks, soybeans
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19
Q

Function of phospholipids

A
  • emulsifier
  • part of the cell membrane (phospholipid bilayer)
  • helps with fat digestion/ absorption forming micelles (lecithin+ bile salts+ electrolytes= bile)
  • helps transport dietary fats in circulation (phospholipid shell)
  • in food: emulsifier (mayonnaise, salad dressing)
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20
Q

Lipids digestion, absorption, and transport

A
  • TG are large: hard for lipase to reach
  • bile: emulsifies fat, making smaller droplets called micelles
  • micelles: water soluble and stay suspended in water based intestinal content
  • lipase
  • monoglycerides and FFA are absorbed
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21
Q

Phospholipids shell of lipoproteins

A
  • transports lipids and chilesterol in the blood
  • phospholipids shell
  • protein
  • TG and chol rich interior
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22
Q

Sterols

A
  • rings of carbon
  • found in food and made in body
  • cholesterol is most common dietary sterol
    • synthesized by animals amd humans, not plants
  • plants make differeny sterols: actually healthy and may reduce cholesterol
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23
Q

Cholesterol functions

A
- base structure of
    • bile salt precursor; bile salts make bile
    • vitamin D
    • hormones: testosterone, estrogen 
- cell membrane structure
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24
Q

Cholesterol (a sterol)

A
  • sources: produced by animals= animal product
  • non essential: liver makes cholesterol
  • health: raises LDL cholesterol
  • dietary guidelines:
    • <300 mg/d
    3oz meat= 100mg
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25
Q

Lipid digestion

A
  • mouth: not much
  • stomach: gastric lipase
  • SI:
    • CCK: stimulates gall bladder to release bile and pancreatic lipase
    • brush border lipase
    • bile emulsifies to form micelle
    • liases hydrolyze TG into monoglycerides and two free fatty acids
26
Q

Lipids in the body: absoprtion and transport

A
  • in the enterocyte
    • short and medium chain FA enter capillary and circulation
    • long chain FA reassemble into TG
    ~ combine with cholesterol, phospholipids and small protein
  • you now have a lipoprotein called a chylomicron
  • chylomicrons enter thr lymph then the blood stream
27
Q

4 differeny lipoprotein

A
  • chylomicrons: the least dense b/c it had lots if triglycerides (85%)
  • very low density lipoprotein (VLDL): 55% triglycerides
  • low density lipoprotein (LDL)
  • high density lipoprotein (HDL)
28
Q

Fat transport: chylomicrons

A
  • chylomicrons carry dietary triglycerides and chilesterol to cells
  • fatty acids and glycerol are taken up by cells
  • fatty acids
    • used as fuel: especiallyin muscle cells
    • resynthesized to TG in adipose cells for storage
  • remaining particle (chylomicron remnant) is full of cholesterol travels to the liver
29
Q

Fat transport: other players

A
  • cholesterol and endogenous TG (lipogenesis) are packed up and carried by:
  • VLDL: delivers TG from the liver to tissue cells
  • LDL: delivers cholesterol to tissues
  • HDL: removes chilesterol from cells and delivers to liver
30
Q

Fat transport: liver

A

Liver makes TG from excess CHO, alcohol and protein(lipogenesis)

  • making fat from nonfat substances
  • in liver cells
  • far carried in VLDL protein
  • glucose, alcohol, and protein all can be made to acetyl CoA to be made into fatty acids
31
Q

Very low density lipoprotein (VLDL)

A

Delivery of dietary an other fatty acids

  • loss of fatty acids
  • made in liver, carried endogenous TG and chilesterol to blood cells, TG rich
32
Q

Intermediate density lipoprotein (IDL)

A

Delivery of dietary and other fatty acids

- loss of fatty acids

33
Q

Low density lipoprotein (LDL)

A

Delivery of cholesterol to body cells

34
Q

High density lipoprotein (HDL)

A

Picking up (scavenging) excess cholesterol from cells for delivery back to the liver

35
Q

Energy from triglycerides

A
  • fatty and glycerol release into curculation
  • glycerol –> pyruvate –> acetyl CoA –> TCA
  • FFA –> beta oxidation –> acetyl CoA –> TCA
  • electrons carried to ETC
36
Q

Beta oxidation

A
  • works on fatty acids from triglycerides
  • occurs in the mitochondria
  • chopping off two carbons at a time and it connected to conenzyme and made into an acetyl CoA
  • the total becomes 8 acetyl CoA
  • glucose only makes 2 acetyl CoA
37
Q

Carbs assist in fat metabolism: acetyl CoA to the TCA cycle

A
  • acetylc CoA combines with oxaloacetate at the first step in the TCA
  • acetyl CoA concentration rise with FA metabolism
  • oxaloacetate is maintained by pyruvate, primarily from CHO
38
Q

Ketone bodies

A
  • made when there is excess acetyl CoA
    • used for energy
    • accumulte in blood
    • excreted in urine
39
Q

Ketones are used for energy

A
  • converted back to acetyl CoA and enter TCA cycle

- oxaloacetate being formed from glycerol, protein (muscle and organs), CHO as they are available

40
Q

Cardiovascular disease

A

Abnormal condition of the heart and blood vessels

41
Q

Atherosclerosis

A

Narrowing and hardening of blood vessels that supply blood to the heart muscle, brain an other parts if thr body
- when plaque is being built up in your blood vessels

42
Q

Coronary heart disease (CHD)

A

Heart not receiving enough blood

43
Q

Stroke

A

Brain not receiving enough blood

44
Q

Dietary factors that promote heart disease

A
  • dietary cholesterol: increase LDL cholesterol
  • saturated fat: increase LDL cholesterol
  • trans fatty acids: increase LDL C and decrease HDL C
  • excess carbs: increase TG, decrease HDL C
  • excess energy; increase body fat, increase risk of diabetes

Saturated fat will have a greater affect in thr LDL C than the dietary cholesterol

45
Q

Heart healthy diet

A
  • low sat fat (25g daily (10-25g soluble for cholesterol lowering, optional)
  • 2-3g of plant sterols, optional
  • limit added sugars: <6 tsp for women, and 9 tsp for men
  • omega 3 fatty acids
  • excercise
  • nuts, fruits, and vegetables, and whole grains
46
Q

Soluble fiber: health benefits

A
  • lowers cholesterol
  • soluble fiber binds with bile salts/acids
    • decrease reabsorption of bile salts/acid
    • increase hepatic conversion of cholesterol to bile acids
    • decrease saturated fat/ cholesterol absorbed= decrease LDL-C
  • AHA recommends 10-25g of soluble fiber daily to lower cholesterol
47
Q

Plant sterols: sitosterol

A
  • found in plants
  • blocks cholesterol absorption by competing with cholesterol space in te micelle
  • 2-3g lowers cholesterol by 10%
  • fortified margarines
48
Q

Olive oil

A

-reduced oxidation of LDL, inflammation, endothelial dysfunction, blood pressure, and blood clotting
- although probable benefits, potential concerns exist
• calories! (120/1 tbs)
• no independent effect on LDL-C lowering
• no RCTs of isolated MUFA or olive oil on morality or heart disease mortality
• olive oil can be processed an losed functionality
• data in monkeys shows similar extent of atherosclerosis in MUFA rich diet as compared to a diet high in saturated fat

49
Q

Foods contributing to the health benefits of a mediterranean diet

A
  • olive oil
  • alcohol
  • nuts (1oz 5x/week)
  • low meat: SF content
  • beans and legunes: SF content, fiber, antioxidants, phytochemicals
  • fruits and veg: fiber, antioxidants, phytochemicals
  • omega 3 fatty acids (crete: purslane, snails, eggs, meat), supported by multiple randomized control trials
50
Q

Mega dose vitamins

A
  • mega dose supplements have not shown to be beneficial
  • recent studies have shown increase risk of death in high risk people with vit A, E, Bs, beta carotene
    • vit E and beta carotene doses were much larger than a multi vit. Supplement
    • vit A doses equivalent to multi vit supplement doses
51
Q

Should we supplement omega 3s?

A
  • omega 3 fatty acids produce beneficial eicosanoids (reduce inflammation, blood clotting, and acts as vasodilators) and protect against heart disease
  • fish consumption= decrease CVD in people without heart disease
  • omega 3 capsules studies have decrease CVD in people with a heartattack
  • omega 3 capsule have resulted harm in men taking nitrate medication with large fih oul consumption and recents studies hve found no benefit or harm
52
Q

Omega 3s are rich in whih foods?

A
  • fish
  • canola
  • walnuts
  • flax
53
Q

Should we supplement B vits?

A
  • B6, B12, and folic acid lower homocysteine, a risk marker for heart disease
  • supplements in doses higer than a multi-vit have shown to increase the risk of death in high risk people (2 studies)
  • eat the food
54
Q

Mediterranean diet: how to do it

A
  • eat lots of veg
  • have smaller amounts if meat
  • eat fish twice a week
  • eat healthy fats: canila, walnut, and olive oil
  • cook vegetarian meals one a week
  • eat fruit for dessert
55
Q

The mediterrean diet

A
  • observational data and radomized data show people that eat a mediterranean diet have lower rates of cardiovascular disease
  • 28-30% reduced risk of CVD events
56
Q

Vegetarian diets

A
  • have reduced CVD, regression of atherosclerosis, reduced mortality
58
Q

Types of vegeterian diets

A
  • vegan:a person who eats only plant foods
  • lacto-vegetarian: a person who consumes only plant products and dairy products (no eggs)
  • ovo-vegetarian:a person who consumes only plant products and eggs
  • lacto-ovo-vegetarian: a person who consumes plant products, dairy products and eggs
  • pescetarian: a person who consumes plant products but excludes all animal flesh except for seafood products
59
Q

Benefits of a vegetarian diet

A
  • nutritents
  • cost
  • environment
  • health
    • Lower body weight (usually)
    • Heart disease
    • Blood pressure
    • Digestion, constipation
    • Cancer: prostate and colorectal
60
Q

Concerns of a vegetarian diet

A
  • B12:naturally found only in animal products
  • iron and zinc: meat is a rich source, less bioavailable from plants
  • calcium/vit D
  • EPA/DHA
  • protein
61
Q

How to plan for a vegetarian diet

A
  • protein: legumes, soy, nuts, seeds, whole grain
    • Complementary proteins: legume + grain/nut/seed
  • iron: leafy greens, dried fruit, whole grains, lentils, fortified products
  • zinc: whole grains, lentils, seeds
  • B12: fortified cereal and soymilk, multivits
  • omega 3 fatty acids: plant sources
  • calcium: fortified tofu, soymilk, orange juice and cereal, broccoli
    * Calcium needs to work with Vit D so that it can work
  • Vit D: sun exposure or fortified soymilk amd cereal
62
Q

Vegetarian Diet is high in….

A
  • Complext carbs
  • Fiber
  • Vitamins E and C and folic acids
  • Carotenoids
  • Phytochemicals
63
Q

vegetarian diet is low in (usually)…

A
  • Calories
  • Saturated fat
  • Cholesterol